ID:AT11C_HUMAN DESCRIPTION: RecName: Full=Probable phospholipid-transporting ATPase IG; EC=3.6.3.1; AltName: Full=ATPase IQ; AltName: Full=ATPase class VI type 11C; CATALYTIC ACTIVITY: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out). SUBUNIT: Interacts with TMEM30A, but not with TMEM30B. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=Efficient exit from the endoplasmic reticulum requires the presence of TMEM30A. Some cell membrane localization observed in the presence of TMEM30B. TISSUE SPECIFICITY: Widely expressed. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. SEQUENCE CAUTION: Sequence=BAC03692.1; Type=Erroneous initiation; Sequence=BAC86172.1; Type=Erroneous initiation; Sequence=BAC86377.1; Type=Erroneous initiation; Sequence=BAD18440.1; Type=Erroneous initiation; Sequence=CAI39713.1; Type=Erroneous gene model prediction; Sequence=CAI39714.1; Type=Erroneous gene model prediction; Sequence=CAI39716.1; Type=Erroneous gene model prediction; Sequence=CAI40418.1; Type=Erroneous gene model prediction; Sequence=CAI41444.1; Type=Erroneous gene model prediction; Sequence=CAI41445.1; Type=Erroneous gene model prediction; Sequence=CAI41446.1; Type=Erroneous gene model prediction; Sequence=CAI41447.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NB49
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002329 pre-B cell differentiation GO:0006869 lipid transport GO:0015914 phospholipid transport GO:0034220 ion transmembrane transport GO:0045332 phospholipid translocation GO:0045579 positive regulation of B cell differentiation
BX648981 - Homo sapiens mRNA; cDNA DKFZp779E2420 (from clone DKFZp779E2420). AK093835 - Homo sapiens cDNA FLJ36516 fis, clone TRACH2001898. AK125476 - Homo sapiens cDNA FLJ43487 fis, clone OCBBF3004264, moderately similar to Mus musculus putative E1-E2 ATPase. AK125474 - Homo sapiens cDNA FLJ43485 fis, clone OCBBF3003320, moderately similar to Potential phospholipid-transporting ATPase IS (EC 3.6.3.13). AJ580093 - Homo sapiens mRNA for ATPase, Class VI, type 11C (ATP11C gene). AJ580094 - Homo sapiens mRNA for ATPase, Class VI, type 11C (ATP11C gene), alternative splice product. BX648320 - Homo sapiens mRNA; cDNA DKFZp686G09145 (from clone DKFZp686G09145). D16467 - Homo sapiens mRNA, Xq terminal portion. AK091552 - Homo sapiens cDNA FLJ34233 fis, clone FCBBF3026048, highly similar to Mus musculus putative E1-E2 ATPase mRNA. AX747055 - Sequence 580 from Patent EP1308459. JD059620 - Sequence 40644 from Patent EP1572962. JD265371 - Sequence 246395 from Patent EP1572962. JD553099 - Sequence 534123 from Patent EP1572962. JD296418 - Sequence 277442 from Patent EP1572962. JD087318 - Sequence 68342 from Patent EP1572962. JD352211 - Sequence 333235 from Patent EP1572962. JD566569 - Sequence 547593 from Patent EP1572962. JD554312 - Sequence 535336 from Patent EP1572962. JD291551 - Sequence 272575 from Patent EP1572962. JD359504 - Sequence 340528 from Patent EP1572962. JD060511 - Sequence 41535 from Patent EP1572962. JD202112 - Sequence 183136 from Patent EP1572962. BC132728 - Homo sapiens ATPase, class VI, type 11C, mRNA (cDNA clone IMAGE:40146750). BC132730 - Homo sapiens ATPase, class VI, type 11C, mRNA (cDNA clone IMAGE:40146752). JD213979 - Sequence 195003 from Patent EP1572962. JD298881 - Sequence 279905 from Patent EP1572962. JD300642 - Sequence 281666 from Patent EP1572962. JD504129 - Sequence 485153 from Patent EP1572962. JD040374 - Sequence 21398 from Patent EP1572962. JD334988 - Sequence 316012 from Patent EP1572962. JD363942 - Sequence 344966 from Patent EP1572962. JD313623 - Sequence 294647 from Patent EP1572962. JD194193 - Sequence 175217 from Patent EP1572962. AK131262 - Homo sapiens cDNA FLJ16194 fis, clone BRTHA2018443, moderately similar to POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE IS (EC 3.6.1.-). AK125986 - Homo sapiens cDNA FLJ43998 fis, clone TESTI4021478, moderately similar to Potential phospholipid-transporting ATPase IS (EC 3.6.3.13). JD182312 - Sequence 163336 from Patent EP1572962. BC172372 - Synthetic construct Homo sapiens clone IMAGE:100069066, MGC:199077 ATPase, class VI, type 11C (ATP11C) mRNA, encodes complete protein.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8NB49 (Reactome details) participates in the following event(s):
R-HSA-939763 P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane R-HSA-947591 P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane R-HSA-936837 Ion transport by P-type ATPases R-HSA-983712 Ion channel transport R-HSA-382551 Transport of small molecules
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