Mouse Gene Sulf1 (ENSMUST00000177608.7) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus sulfatase 1 (Sulf1), transcript variant 1, mRNA. (from RefSeq NM_001198565)
Gencode Transcript: ENSMUST00000177608.7
Gencode Gene: ENSMUSG00000016918.15
Transcript (Including UTRs)
   Position: mm10 chr1:12,692,277-12,861,192 Size: 168,916 Total Exon Count: 22 Strand: +
Coding Region
   Position: mm10 chr1:12,786,527-12,858,842 Size: 72,316 Coding Exon Count: 19 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:12,692,277-12,861,192)mRNA (may differ from genome)Protein (870 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: SULF1_MOUSE
DESCRIPTION: RecName: Full=Extracellular sulfatase Sulf-1; Short=mSulf-1; EC=3.1.6.-; Flags: Precursor;
FUNCTION: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation (By similarity).
COFACTOR: Binds 1 calcium ion per subunit (By similarity).
SUBCELLULAR LOCATION: Endoplasmic reticulum (By similarity). Golgi apparatus, Golgi stack (By similarity). Cell surface (By similarity). Note=Also localized on the cell surface (By similarity).
PTM: The conversion to 3-oxoalanine (also known as C- formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity (By similarity).
SIMILARITY: Belongs to the sulfatase family.
SEQUENCE CAUTION: Sequence=BAC32179.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=BAC98088.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC98088.1; Type=Miscellaneous discrepancy; Note=Intron retention. The sequence is a pre-RNA and intronic sequences remain;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -189.30635-0.298 Picture PostScript Text
3' UTR -700.702350-0.298 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017849 - Alkaline_Pase-like_a/b/a
IPR017850 - Alkaline_phosphatase_core
IPR014615 - Extracellular_sulfatase
IPR024609 - Extracellular_sulfatase_C
IPR000917 - Sulfatase
IPR024607 - Sulfatase_CS

Pfam Domains:
PF00884 - Sulfatase
PF12548 - Sulfatase protein

SCOP Domains:
53649 - Alkaline phosphatase-like

ModBase Predicted Comparative 3D Structure on Q8K007
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003824 catalytic activity
GO:0004065 arylsulfatase activity
GO:0005509 calcium ion binding
GO:0008449 N-acetylglucosamine-6-sulfatase activity
GO:0008484 sulfuric ester hydrolase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

Biological Process:
GO:0001502 cartilage condensation
GO:0001822 kidney development
GO:0001937 negative regulation of endothelial cell proliferation
GO:0002063 chondrocyte development
GO:0003094 glomerular filtration
GO:0006790 sulfur compound metabolic process
GO:0006915 apoptotic process
GO:0007155 cell adhesion
GO:0008152 metabolic process
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0014846 esophagus smooth muscle contraction
GO:0016525 negative regulation of angiogenesis
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030201 heparan sulfate proteoglycan metabolic process
GO:0030336 negative regulation of cell migration
GO:0030513 positive regulation of BMP signaling pathway
GO:0032836 glomerular basement membrane development
GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway
GO:0036022 limb joint morphogenesis
GO:0040036 regulation of fibroblast growth factor receptor signaling pathway
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048706 embryonic skeletal system development
GO:0051216 cartilage development
GO:0060348 bone development
GO:0060384 innervation
GO:0060686 negative regulation of prostatic bud formation

Cellular Component:
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005795 Golgi stack
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0045121 membrane raft


-  Descriptions from all associated GenBank mRNAs
  AK078756 - Mus musculus 15 days embryo male testis cDNA, RIKEN full-length enriched library, clone:8030446E18 product:SULFATASE FP homolog [Rattus norvegicus], full insert sequence.
AK129278 - Mus musculus premature mRNA for mKIAA1077 protein.
AK045002 - Mus musculus 9.5 days embryo parthenogenote cDNA, RIKEN full-length enriched library, clone:B130018L10 product:SULFATASE FP homolog [Rattus norvegicus], full insert sequence.
AK028285 - Mus musculus 14, 17 days embryo head cDNA, RIKEN full-length enriched library, clone:3230401B12 product:SULFATASE FP homolog [Rattus norvegicus], full insert sequence.
AY101178 - Mus musculus extracellular sulfatase SULF-1 mRNA, complete cds.
BC034547 - Mus musculus sulfatase 1, mRNA (cDNA clone MGC:25096 IMAGE:4500954), complete cds.
BC049276 - Mus musculus sulfatase 1, mRNA (cDNA clone MGC:55013 IMAGE:4500954), complete cds.
AK076327 - Mus musculus 10 days neonate skin cDNA, RIKEN full-length enriched library, clone:4732435E20 product:SULFATASE FP homolog [Rattus norvegicus], full insert sequence.
AK037389 - Mus musculus 16 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A130013J22 product:sulfatase 1, full insert sequence.
AK054518 - Mus musculus 2 days pregnant adult female ovary cDNA, RIKEN full-length enriched library, clone:E330036C08 product:unclassifiable, full insert sequence.
AK081929 - Mus musculus 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130087O04 product:SULFATASE FP homolog [Rattus norvegicus], full insert sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: Kiaa1077, NM_001198565, Q6ZPZ0, Q8BLJ0, Q8C1D3, Q8K007, SULF1_MOUSE, uc007aia.1, uc007aia.2, uc007aia.3
UCSC ID: uc007aia.3
RefSeq Accession: NM_001198565
Protein: Q8K007 (aka SULF1_MOUSE or SUL1_MOUSE)
CCDS: CCDS14820.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.