ID:SULF1_MOUSE DESCRIPTION: RecName: Full=Extracellular sulfatase Sulf-1; Short=mSulf-1; EC=3.1.6.-; Flags: Precursor; FUNCTION: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation (By similarity). COFACTOR: Binds 1 calcium ion per subunit (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum (By similarity). Golgi apparatus, Golgi stack (By similarity). Cell surface (By similarity). Note=Also localized on the cell surface (By similarity). PTM: The conversion to 3-oxoalanine (also known as C- formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity (By similarity). SIMILARITY: Belongs to the sulfatase family. SEQUENCE CAUTION: Sequence=BAC32179.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=BAC98088.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC98088.1; Type=Miscellaneous discrepancy; Note=Intron retention. The sequence is a pre-RNA and intronic sequences remain;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8K007
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.