ID:AP2B_MOUSE DESCRIPTION: RecName: Full=Transcription factor AP-2-beta; Short=AP2-beta; AltName: Full=Activating enhancer-binding protein 2-beta; FUNCTION: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. SUBUNIT: Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity (By similarity). SUBCELLULAR LOCATION: Nucleus (Probable). DEVELOPMENTAL STAGE: Expressed from embryo day 9.5 to birth. In day 13.5 embryo, expressed abundantly in cells coating the neural tube. Expression continues posteriorly in the spinal cord, the dorsal root ganglia, in the prevertebal sympathic ganglia and the ganglion nodosum. High expression found in the dorsal and anteriolateral primordium of the midbrain. Expression also found in skin, kidneys and in many areas of the facial mesenchyme. In adults, expressed in the eye, skin, kidney, prostate, thymus, skeletal muscle and, very weakly in the brain. Highest levels found in kidney. INDUCTION: During retinoic acid-mediated differentiation. PTM: Sumoylated on Lys-21; which inhibits transcriptional activity (By similarity). SIMILARITY: Belongs to the AP-2 family. SEQUENCE CAUTION: Sequence=CAA55036.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q61313
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001105 RNA polymerase II transcription coactivator activity GO:0001106 RNA polymerase II transcription corepressor activity GO:0001158 enhancer sequence-specific DNA binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003713 transcription coactivator activity GO:0003714 transcription corepressor activity GO:0005515 protein binding GO:0042803 protein homodimerization activity GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043565 sequence-specific DNA binding GO:0046982 protein heterodimerization activity GO:0046983 protein dimerization activity
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001822 kidney development GO:0003091 renal water homeostasis GO:0006006 glucose metabolic process GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006915 apoptotic process GO:0007423 sensory organ development GO:0008284 positive regulation of cell proliferation GO:0008285 negative regulation of cell proliferation GO:0010226 response to lithium ion GO:0010842 retina layer formation GO:0010960 magnesium ion homeostasis GO:0030510 regulation of BMP signaling pathway GO:0035136 forelimb morphogenesis GO:0035137 hindlimb morphogenesis GO:0035810 positive regulation of urine volume GO:0035909 aorta morphogenesis GO:0042493 response to drug GO:0042593 glucose homeostasis GO:0043066 negative regulation of apoptotic process GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0043525 positive regulation of neuron apoptotic process GO:0043588 skin development GO:0045444 fat cell differentiation GO:0045595 regulation of cell differentiation GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048485 sympathetic nervous system development GO:0050796 regulation of insulin secretion GO:0055062 phosphate ion homeostasis GO:0055074 calcium ion homeostasis GO:0055075 potassium ion homeostasis GO:0055078 sodium ion homeostasis GO:0072017 distal tubule development GO:0072044 collecting duct development GO:0072210 metanephric nephron development GO:0097070 ductus arteriosus closure GO:0097275 cellular ammonia homeostasis GO:0097276 cellular creatinine homeostasis GO:0097277 cellular urea homeostasis
Protein Q61313 (Reactome details) participates in the following event(s):
R-MMU-8864595 TFAP2B homodimer binds YEATS4 R-MMU-8864278 AP-2 (TFAP2) transcription factors form homo- and heterodimers R-MMU-8864307 TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP R-MMU-8864343 KCTD1 binds TFAP2 homo- and heterodimers R-MMU-8866907 Activation of the TFAP2 (AP-2) family of transcription factors R-MMU-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-MMU-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-MMU-212436 Generic Transcription Pathway R-MMU-73857 RNA Polymerase II Transcription R-MMU-74160 Gene expression (Transcription)