Mouse Gene Ugt1a5 (ENSMUST00000097659.4) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus UDP glucuronosyltransferase 1 family, polypeptide A5 (Ugt1a5), mRNA. (from RefSeq NM_201643)
Gencode Transcript: ENSMUST00000097659.4
Gencode Gene: ENSMUSG00000089943.1
Transcript (Including UTRs)
   Position: mm10 chr1:88,166,012-88,218,997 Size: 52,986 Total Exon Count: 5 Strand: +
Coding Region
   Position: mm10 chr1:88,166,052-88,218,424 Size: 52,373 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:88,166,012-88,218,997)mRNA (may differ from genome)Protein (529 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: B2RT14_MOUSE
DESCRIPTION: SubName: Full=MCG14318, isoform CRA_h; SubName: Full=Protein Ugt1a5; SubName: Full=UDP glucuronosyltransferase 1 family, polypeptide A5;
SIMILARITY: Belongs to the UDP-glycosyltransferase family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.3040-0.133 Picture PostScript Text
3' UTR -134.30573-0.234 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002213 - UDP_glucos_trans

Pfam Domains:
PF00201 - UDP-glucoronosyl and UDP-glucosyl transferase
PF04101 - Glycosyltransferase family 28 C-terminal domain

SCOP Domains:
48201 - Uteroglobin-like
53756 - UDP-Glycosyltransferase/glycogen phosphorylase

ModBase Predicted Comparative 3D Structure on B2RT14
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0015020 glucuronosyltransferase activity
GO:0016740 transferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0016758 transferase activity, transferring hexosyl groups
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity

Biological Process:
GO:0008152 metabolic process
GO:0052695 cellular glucuronidation
GO:0052696 flavonoid glucuronidation
GO:0052697 xenobiotic glucuronidation

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  BC089569 - Mus musculus UDP glycosyltransferase 1 family, polypeptide A10, mRNA (cDNA clone MGC:107546 IMAGE:30120494), complete cds.
AY227201 - Mus musculus UDP glycosyltransferase 1 family polypeptide A13 (Ugt1a13) mRNA, complete cds.
BC146021 - Mus musculus UDP glucuronosyltransferase 1 family, polypeptide A9, mRNA (cDNA clone MGC:175908 IMAGE:40131324), complete cds.
BC138699 - Mus musculus UDP glucuronosyltransferase 1 family, polypeptide A9, mRNA (cDNA clone MGC:170326 IMAGE:8861721), complete cds.
AY227200 - Mus musculus UDP glycosyltransferase 1 family polypeptide A12 (Ugt1a12) mRNA, complete cds.
BC019434 - Mus musculus UDP glucuronosyltransferase 1 family, polypeptide A9, mRNA (cDNA clone IMAGE:5126634).
L27122 - Mus musculus (A-1) bilirubin/phenol UDP-glucuronosyltransferase (UGTBr/p) mRNA, complete cds.
AK159496 - Mus musculus osteoclast-like cell cDNA, RIKEN full-length enriched library, clone:I420021K01 product:UDP glycosyltransferase 1 family, polypeptide A10, full insert sequence.
AK128918 - Mus musculus cDNA fis, clone TRACH2025057, highly similar to UDP-glucuronosyltransferase 1-7 precursor, microsomal (EC 2.4.1.17).
AK162317 - Mus musculus adult male colon cDNA, RIKEN full-length enriched library, clone:9030623M03 product:UDP glycosyltransferase 1 family, polypeptide A10, full insert sequence.
AK165465 - Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:F530009N23 product:UDP glycosyltransferase 1 family, polypeptide A10, full insert sequence.
AK154973 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630113I01 product:UDP glycosyltransferase 1 family, polypeptide A10, full insert sequence.
BC141205 - Mus musculus UDP glucuronosyltransferase 1 family, polypeptide A7C, mRNA (cDNA clone MGC:176166 IMAGE:9055817), complete cds.
BC141206 - Mus musculus UDP glucuronosyltransferase 1 family, polypeptide A7C, mRNA (cDNA clone MGC:176167 IMAGE:9055818), complete cds.
AY227199 - Mus musculus UDP glycosyltransferase 1 family polypeptide A10 (Ugt1a10) mRNA, complete cds.
AK144599 - Mus musculus lung RCB-0558 LLC cDNA, RIKEN full-length enriched library, clone:G730007L19 product:UDP glycosyltransferase 1 family, polypeptide A10, full insert sequence.
AK153157 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830125J06 product:UDP glycosyltransferase 1 family, polypeptide A10, full insert sequence.
BC026561 - Mus musculus UDP glucuronosyltransferase 1 family, polypeptide A6B, mRNA (cDNA clone MGC:36247 IMAGE:5050488), complete cds.
AY227198 - Mus musculus UDP glycosyltransferase 1 family polypeptide A9 (Ugt1a9) mRNA, complete cds.
U16818 - Mus musculus UDP glucuronosyltransferase (UGT1-06) mRNA, complete cds.
AK162514 - Mus musculus adult male urinary bladder cDNA, RIKEN full-length enriched library, clone:9530044G16 product:UDP glycosyltransferase 1 family, polypeptide A6, full insert sequence.
BC069940 - Mus musculus UDP glucuronosyltransferase 1 family, polypeptide A6A, mRNA (cDNA clone MGC:78240 IMAGE:5249697), complete cds.
AY227197 - Mus musculus UDP glycosyltransferase 1 family polypeptide A7 (Ugt1a7) mRNA, complete cds.
U09930 - Mus musculus UGT1.6 mRNA, complete cds.
D87867 - Mus musculus mRNA for phenol UDP-glucuronosyltransferase, complete cds.
AY227196 - Mus musculus UDP glycosyltransferase 1 family polypeptide A5 (Ugt1a5) mRNA, complete cds.
BC139093 - Mus musculus UDP glucuronosyltransferase 1 family, polypeptide A5, mRNA (cDNA clone MGC:170720 IMAGE:8862115), complete cds.
BC139094 - Mus musculus UDP glucuronosyltransferase 1 family, polypeptide A5, mRNA (cDNA clone MGC:170721 IMAGE:8862116), complete cds.
BC165969 - Synthetic construct Mus musculus clone IMAGE:100066269, MGC:195406 UDP glucuronosyltransferase 1 family, polypeptide A5 (Ugt1a5) mRNA, encodes complete protein.
AB094481 - Mus musculus LE137 mRNA for hypothetical protein, complete cds, similar to Rat UGT1A5.
AY227195 - Mus musculus UDP glycosyltransferase 1 family polypeptide A2 (Ugt1a2) mRNA, complete cds.
AK002629 - Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:0610013P07 product:UDP-glucuronosyltransferase 1 family, member 1, full insert sequence.
BC138676 - Mus musculus UDP glucuronosyltransferase 1 family, polypeptide A2, mRNA (cDNA clone MGC:170302 IMAGE:8861697), complete cds.
BC145969 - Mus musculus UDP glucuronosyltransferase 1 family, polypeptide A2, mRNA (cDNA clone MGC:175856 IMAGE:40131272), complete cds.
D87866 - Mus musculus mRNA for bilirubin UDP-glucuronosyltransferase, complete cds.
AY227194 - Mus musculus UDP glycosyltransferase 1 family polypeptide A1 (Ugt1a1) mRNA, complete cds.
LF192775 - JP 2014500723-A/278: Polycomb-Associated Non-Coding RNAs.
L02333 - Murine bilirubin/phenol family UDP glucuronosyltransferase (ugtBr) mRNA sequence.
S64760 - UGTBr1=UDP-glucuronosyltransferase [mice, mRNA, 2215 nt].
BC093516 - Mus musculus UDP glucuronosyltransferase 1 family, polypeptide A1, mRNA (cDNA clone MGC:103216 IMAGE:5135493), complete cds.
JX026002 - Mus musculus strain C57BL/6J UDP glucuronosyltransferase 1 family polypeptide A1 (Ugt1a1) mRNA, complete cds, alternatively spliced.
LF216945 - JP 2014500723-A/24448: Polycomb-Associated Non-Coding RNAs.
LF216946 - JP 2014500723-A/24449: Polycomb-Associated Non-Coding RNAs.
LF216948 - JP 2014500723-A/24451: Polycomb-Associated Non-Coding RNAs.
LF216949 - JP 2014500723-A/24452: Polycomb-Associated Non-Coding RNAs.
MA428352 - JP 2018138019-A/278: Polycomb-Associated Non-Coding RNAs.
MA452522 - JP 2018138019-A/24448: Polycomb-Associated Non-Coding RNAs.
MA452523 - JP 2018138019-A/24449: Polycomb-Associated Non-Coding RNAs.
MA452525 - JP 2018138019-A/24451: Polycomb-Associated Non-Coding RNAs.
MA452526 - JP 2018138019-A/24452: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu00040 - Pentose and glucuronate interconversions
mmu00053 - Ascorbate and aldarate metabolism
mmu00140 - Steroid hormone biosynthesis
mmu00500 - Starch and sucrose metabolism
mmu00514 - Other types of O-glycan biosynthesis
mmu00830 - Retinol metabolism
mmu00860 - Porphyrin and chlorophyll metabolism
mmu00980 - Metabolism of xenobiotics by cytochrome P450
mmu00982 - Drug metabolism - cytochrome P450
mmu00983 - Drug metabolism - other enzymes
mmu01100 - Metabolic pathways

Reactome (by CSHL, EBI, and GO)

Protein B2RT14 (Reactome details) participates in the following event(s):

R-MMU-159179 UGT1A1 tetramer, UGT1A4 transfer GlcA from UDP-GlcA to BMG to form BDG
R-MMU-159194 UGT1A1,4 transfer GlcA from UDP-GlcA to BIL to form BMG
R-MMU-174916 Formation of N-glucuronides
R-MMU-174931 UGTs transfer GlcA from UDP-GlcA to O-centre substrates
R-MMU-156588 Glucuronidation
R-MMU-189483 Heme degradation
R-MMU-156580 Phase II - Conjugation of compounds
R-MMU-189445 Metabolism of porphyrins
R-MMU-211859 Biological oxidations
R-MMU-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: B2RT14, B2RT14_MOUSE, mCG_14318, NM_201643, uc007byh.1, uc007byh.2
UCSC ID: uc007byh.2
RefSeq Accession: NM_201643
Protein: B2RT14 CCDS: CCDS35659.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.