ID:NDUAA_MOUSE DESCRIPTION: RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; AltName: Full=Complex I-42kD; Short=CI-42kD; AltName: Full=NADH-ubiquinone oxidoreductase 42 kDa subunit; Flags: Precursor; FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). COFACTOR: Binds 1 FAD per subunit. SUBUNIT: Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction (By similarity). SUBCELLULAR LOCATION: Mitochondrion matrix. PTM: Acetylation of Lys-242 is observed in liver mitochondria from fasted mice but not from fed mice. SIMILARITY: Belongs to the complex I NDUFA10 subunit family. SEQUENCE CAUTION: Sequence=BAB23961.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99LC3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006120 mitochondrial electron transport, NADH to ubiquinone GO:0032981 mitochondrial respiratory chain complex I assembly GO:0055114 oxidation-reduction process
BioCyc Knowledge Library PWY-3781 - aerobic respiration -- electron donor II PWY0-1334 - NADH to cytochrome bd oxidase electron transfer PWY0-1335 - NADH to cytochrome bo oxidase electron transfer
Reactome (by CSHL, EBI, and GO)
Protein Q99LC3 (Reactome details) participates in the following event(s):
R-MMU-6799178 Intermediate 1 binds HP subcomplex to form Intermediate 2 R-MMU-6799191 Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex R-MMU-6799202 The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex R-MMU-6799197 ND4, ND5 bind the 550kDa complex to form the 815kDa complex R-MMU-6799179 Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex R-MMU-6799196 The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I R-MMU-163217 Complex I oxidises NADH to NAD+, reduces CoQ to QH2 R-MMU-6799198 Complex I biogenesis R-MMU-611105 Respiratory electron transport R-MMU-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-MMU-1428517 The citric acid (TCA) cycle and respiratory electron transport R-MMU-1430728 Metabolism
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