Mouse Gene Rgl1 (ENSMUST00000027760.13) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus ral guanine nucleotide dissociation stimulator,-like 1 (Rgl1), transcript variant 4, mRNA. (from RefSeq NM_016846) RefSeq Summary (NM_016846): This gene encodes a member of the Ras-like (Ral) -selective guanine nucleotide exchange factor (RalGEF) family of small GTPase activators which function both as downstream effectors of activated Ras GTPase and as regulators of certain Ral GTPases in the RalGEF - Ral GTPase signaling pathway. The encoded protein, like other RalGEFs, has an N-terminal ras exchanger motif domain, a catalytic CDC25 homology domain, and a C-terminal ras binding domain that stimulates guanine nucleotide exchange when bound to a Ral GTPase. RalGEF family members bridge the Ras and Ral signaling pathways and are thought to play a role in oncogenic transformation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]. Gencode Transcript: ENSMUST00000027760.13 Gencode Gene: ENSMUSG00000026482.13 Transcript (Including UTRs) Position: mm10 chr1:152,516,951-152,625,217 Size: 108,267 Total Exon Count: 18 Strand: - Coding Region Position: mm10 chr1:152,519,009-152,625,010 Size: 106,002 Coding Exon Count: 18
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q60695
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.