Mouse Gene Pou2f1 (uc007djz.1) Description and Page Index
  Description: POU domain, class 2, transcription factor 1
Transcript (Including UTRs)
   Position: mm9 chr1:167,805,605-167,932,765 Size: 127,161 Total Exon Count: 16 Strand: -
Coding Region
   Position: mm9 chr1:167,805,869-167,932,753 Size: 126,885 Coding Exon Count: 16 

Page IndexSequence and LinksCTDMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2011-03-02

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:167,805,605-167,932,765)mRNA (may differ from genome)Protein (769 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAllen Brain Atlas
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
PubMedReactomeStanford SOURCEUniProtKB

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from GNF1M Mouse Chip

    
     
      
       
     
    
   
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Rinn et. al Sex Gene Expression Data on MOE430A Chip

        
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GNF Expression Atlas Data from U74a Mouse Chip

        
     
    
    
    
   
    
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Affymetrix All Exon Microarrays

           
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -71.24264-0.270 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00046 - Homeobox domain
PF00157 - Pou domain - N-terminal to homeobox domain

SCOP Domains:
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like

ModBase Predicted Comparative 3D Structure on P25425-5
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
GenBankRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Descriptions from all associated GenBank mRNAs
  BC066201 - Mus musculus cDNA clone IMAGE:30472546, containing frame-shift errors.
X68363 - M.musculus mRNA for Oct-1B protein.
X68362 - M.musculus mRNA for Oct-1A protein.
X68364 - M.musculus mRNA for Oct-1C protein.
AF508939 - Mus musculus POU domain transcription factor Oct-1B mRNA, complete cds.
AK028237 - Mus musculus 10, 11 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2810482H01 product:POU domain, class 2, transcription factor 1, full insert sequence.
AY177625 - Mus musculus transcription factor OCT-1Z mRNA, complete cds.
AK044830 - Mus musculus 9.5 days embryo parthenogenote cDNA, RIKEN full-length enriched library, clone:B130006M20 product:POU domain, class 2, transcription factor 1, full insert sequence.
AJ489477 - Mus musculus partial mRNA for ubiquitous transcription factor, isoform Oct-1d (oct-1 gene).
AJ489478 - Mus musculus partial mRNA for ubiquitous transcription factor, isoform Oct-1e (oct-1 gene).
LF192978 - JP 2014500723-A/481: Polycomb-Associated Non-Coding RNAs.
MA428555 - JP 2018138019-A/481: Polycomb-Associated Non-Coding RNAs.
X70325 - M.musculus oct-1 mRNA.
X70324 - M.musculus oct-1 mRNA.
S65461 - gene colinear with CD3 zeta/eta/theta [mice, thymus, mRNA Partial, 2504 nt].
AF095458 - Mus musculus transcription factor Oct-1 isoform 8 (Pou2f1) mRNA, partial cds.
AF095459 - Mus musculus transcription factor Oct-1 isoform 9 (Pou2f1) mRNA, partial cds.
AF095460 - Mus musculus transcription factor Oct-1 isoform 7 (Pou2f1) mRNA, partial cds.
AK082573 - Mus musculus 0 day neonate cerebellum cDNA, RIKEN full-length enriched library, clone:C230064N08 product:POU domain, class 2, transcription factor 1, full insert sequence.
AJ296212 - Mus musculus mRNA for ubiquitous Oct-1L (Oct-1 gene).
BC146305 - Synthetic construct Mus musculus clone IMAGE:100015196, MGC:180421 POU domain, class 2, transcription factor 1 (Pou2f1) mRNA, encodes complete protein.
BC148748 - Synthetic construct Mus musculus clone IMAGE:100015808, MGC:183446 POU domain, class 2, transcription factor 1 (Pou2f1) mRNA, encodes complete protein.
X56230 - Mus musculus OCT-1 mRNA for octamer-binding protein.
AJ489475 - Mus musculus mRNA for ubiquitous transcription factor, isoform Oct-1rb (oct-1 gene).
AJ489474 - Mus musculus mRNA for ubiquitous transcription factor, isoform Oct-1ra (oct-1 gene).
X51958 - Mouse Oct1 gene POU-homeobox region.
HV775951 - JP 2012139197-A/5: DNA oligomer for the Rnase-free method of cDNA/mRNA display.
LF219260 - JP 2014500723-A/26763: Polycomb-Associated Non-Coding RNAs.
LF219261 - JP 2014500723-A/26764: Polycomb-Associated Non-Coding RNAs.
LF219262 - JP 2014500723-A/26765: Polycomb-Associated Non-Coding RNAs.
LF219281 - JP 2014500723-A/26784: Polycomb-Associated Non-Coding RNAs.
LF219288 - JP 2014500723-A/26791: Polycomb-Associated Non-Coding RNAs.
LF219291 - JP 2014500723-A/26794: Polycomb-Associated Non-Coding RNAs.
MA454837 - JP 2018138019-A/26763: Polycomb-Associated Non-Coding RNAs.
MA454838 - JP 2018138019-A/26764: Polycomb-Associated Non-Coding RNAs.
MA454839 - JP 2018138019-A/26765: Polycomb-Associated Non-Coding RNAs.
MA454858 - JP 2018138019-A/26784: Polycomb-Associated Non-Coding RNAs.
MA454865 - JP 2018138019-A/26791: Polycomb-Associated Non-Coding RNAs.
MA454868 - JP 2018138019-A/26794: Polycomb-Associated Non-Coding RNAs.
LF219391 - JP 2014500723-A/26894: Polycomb-Associated Non-Coding RNAs.
MA454968 - JP 2018138019-A/26894: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P25425 (Reactome details) participates in the following event(s):

R-MMU-83791 Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter
R-MMU-9009371 Binding of AP1 transcriptional activator complexes to CCND1 promoter
R-MMU-83793 Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex
R-MMU-83803 Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex
R-MMU-6810239 SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)
R-MMU-6810234 General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene
R-MMU-6810233 CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter
R-MMU-6810238 RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)
R-MMU-6810235 RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain
R-MMU-6814885 CBCAP complex binds 7-methylguanosine cap of snRNA
R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter
R-MMU-9018519 Estrogen-dependent gene expression
R-MMU-76046 RNA Polymerase III Transcription Initiation
R-MMU-8939211 ESR-mediated signaling
R-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-74158 RNA Polymerase III Transcription
R-MMU-9006931 Signaling by Nuclear Receptors
R-MMU-73857 RNA Polymerase II Transcription
R-MMU-74160 Gene expression (Transcription)
R-MMU-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: NM_198932, NP_945150, Oct-1, Otf-1, Otf1, P25425-5
UCSC ID: uc007djz.1
RefSeq Accession: NM_198932
Protein: P25425-5 CCDS: CCDS15444.1, CCDS35760.1, CCDS35761.1, CCDS48430.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_198932.2
exon count: 16CDS single in 3' UTR: no RNA size: 2588
ORF size: 2310CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4812.50frame shift in genome: no % Coverage: 99.92
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 429# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.