ID:CE170_MOUSE DESCRIPTION: RecName: Full=Centrosomal protein of 170 kDa; Short=Cep170; FUNCTION: Plays a role in microtubule organization (By similarity). SUBUNIT: Interacts with PLK1 (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome, centriole (By similarity). Cytoplasm, cytoskeleton, spindle (By similarity). Note=Associated with the mature mother centriole (By similarity). Associated with spindle microtubules during mitosis (By similarity). PTM: Phosphorylated; probably by PLK1. Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). SIMILARITY: Belongs to the CEP170 family. SIMILARITY: Contains 1 FHA domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6A065
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Human
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary