Mouse Gene Tmem63a (ENSMUST00000027800.14) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus transmembrane protein 63a (Tmem63a), mRNA. (from RefSeq NM_144794)
Gencode Transcript: ENSMUST00000027800.14
Gencode Gene: ENSMUSG00000026519.16
Transcript (Including UTRs)
   Position: mm10 chr1:180,942,459-180,975,112 Size: 32,654 Total Exon Count: 23 Strand: +
Coding Region
   Position: mm10 chr1:180,946,580-180,974,336 Size: 27,757 Coding Exon Count: 22 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:180,942,459-180,975,112)mRNA (may differ from genome)Protein (804 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: TM63A_MOUSE
DESCRIPTION: RecName: Full=Transmembrane protein 63A;
SUBCELLULAR LOCATION: Lysosome membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the SPO75/TMEM63 family.
SEQUENCE CAUTION: Sequence=BAD32305.1; Type=Erroneous initiation; Sequence=BAE41880.1; Type=Erroneous termination; Positions=774; Note=Translated as Tyr;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -39.30115-0.342 Picture PostScript Text
3' UTR -299.90776-0.386 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003864 - DUF221
IPR012677 - Nucleotide-bd_a/b_plait
IPR026957 - TMEM63

Pfam Domains:
PF02714 - Calcium-dependent channel, 7TM region, putative phosphate
PF13967 - Late exocytosis, associated with Golgi transport
PF14703 - Cytosolic domain of 10TM putative phosphate transporter

SCOP Domains:
54928 - RNA-binding domain, RBD

ModBase Predicted Comparative 3D Structure on Q91YT8
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0003676 nucleic acid binding

Biological Process:
GO:0006811 ion transport
GO:0008150 biological_process

Cellular Component:
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005815 microtubule organizing center
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  LF202370 - JP 2014500723-A/9873: Polycomb-Associated Non-Coding RNAs.
LF193059 - JP 2014500723-A/562: Polycomb-Associated Non-Coding RNAs.
AK144899 - Mus musculus lung RCB-0558 LLC cDNA, RIKEN full-length enriched library, clone:G730050I17 product:hypothetical protein, full insert sequence.
AK170559 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630107N20 product:hypothetical protein, full insert sequence.
BC019442 - Mus musculus transmembrane protein 63a, mRNA (cDNA clone MGC:25803 IMAGE:4036849), complete cds.
AK049360 - Mus musculus ES cells cDNA, RIKEN full-length enriched library, clone:C330028B17 product:hypothetical protein, full insert sequence.
AK173027 - Mus musculus mRNA for mKIAA0792 protein.
BC014795 - Mus musculus transmembrane protein 63a, mRNA (cDNA clone MGC:11687 IMAGE:3961992), complete cds.
LF220463 - JP 2014500723-A/27966: Polycomb-Associated Non-Coding RNAs.
LF193060 - JP 2014500723-A/563: Polycomb-Associated Non-Coding RNAs.
AK215121 - Mus musculus cDNA, clone:Y2G0134A14, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000027800, based on BLAT search.
LF220468 - JP 2014500723-A/27971: Polycomb-Associated Non-Coding RNAs.
LF220470 - JP 2014500723-A/27973: Polycomb-Associated Non-Coding RNAs.
LF220471 - JP 2014500723-A/27974: Polycomb-Associated Non-Coding RNAs.
LF220473 - JP 2014500723-A/27976: Polycomb-Associated Non-Coding RNAs.
LF220474 - JP 2014500723-A/27977: Polycomb-Associated Non-Coding RNAs.
AK218532 - Mus musculus cDNA, clone:Y2G0145H17, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000027800, based on BLAT search.
AK219713 - Mus musculus cDNA, clone:Y2G0149F18, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000027800, based on BLAT search.
AK211483 - Mus musculus cDNA, clone:Y2G0121O11, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000027800, based on BLAT search.
LF220480 - JP 2014500723-A/27983: Polycomb-Associated Non-Coding RNAs.
LF220481 - JP 2014500723-A/27984: Polycomb-Associated Non-Coding RNAs.
AK196306 - Mus musculus cDNA, clone:Y1G0121H06, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000027800, based on BLAT search.
AK205689 - Mus musculus cDNA, clone:Y2G0102H16, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000027800, based on BLAT search.
MA437947 - JP 2018138019-A/9873: Polycomb-Associated Non-Coding RNAs.
MA428636 - JP 2018138019-A/562: Polycomb-Associated Non-Coding RNAs.
MA456040 - JP 2018138019-A/27966: Polycomb-Associated Non-Coding RNAs.
MA428637 - JP 2018138019-A/563: Polycomb-Associated Non-Coding RNAs.
MA456045 - JP 2018138019-A/27971: Polycomb-Associated Non-Coding RNAs.
MA456047 - JP 2018138019-A/27973: Polycomb-Associated Non-Coding RNAs.
MA456048 - JP 2018138019-A/27974: Polycomb-Associated Non-Coding RNAs.
MA456050 - JP 2018138019-A/27976: Polycomb-Associated Non-Coding RNAs.
MA456051 - JP 2018138019-A/27977: Polycomb-Associated Non-Coding RNAs.
MA456057 - JP 2018138019-A/27983: Polycomb-Associated Non-Coding RNAs.
MA456058 - JP 2018138019-A/27984: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q91YT8 (Reactome details) participates in the following event(s):

R-MMU-6798747 Exocytosis of tertiary granule membrane proteins
R-MMU-6799350 Exocytosis of specific granule membrane proteins
R-MMU-6798695 Neutrophil degranulation
R-MMU-168249 Innate Immune System
R-MMU-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: Kiaa0792, NM_144794, Q3TCS5, Q69ZZ1, Q91YT8, TM63A_MOUSE, uc007dwx.1, uc007dwx.2
UCSC ID: uc007dwx.2
RefSeq Accession: NM_144794
Protein: Q91YT8 (aka TM63A_MOUSE)
CCDS: CCDS15578.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.