The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O08529
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004198 calcium-dependent cysteine-type endopeptidase activity GO:0005509 calcium ion binding GO:0008092 cytoskeletal protein binding GO:0008233 peptidase activity GO:0008234 cysteine-type peptidase activity GO:0016787 hydrolase activity GO:0046872 metal ion binding GO:0046982 protein heterodimerization activity
Biological Process: GO:0001666 response to hypoxia GO:0001824 blastocyst development GO:0006508 proteolysis GO:0007520 myoblast fusion GO:0016540 protein autoprocessing GO:0051493 regulation of cytoskeleton organization GO:0051603 proteolysis involved in cellular protein catabolic process GO:0071230 cellular response to amino acid stimulus
AK154855 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630109M08 product:calpain 2, full insert sequence. BC054726 - Mus musculus calpain 2, mRNA (cDNA clone MGC:65596 IMAGE:5703563), complete cds. D38117 - Mus musculus mRNA for m-calpain large subunit, complete cds. AK150695 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830013M09 product:calpain 2, full insert sequence. AK152094 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830047J04 product:calpain 2, full insert sequence. AK152790 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830086C02 product:calpain 2, full insert sequence. AK152994 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830099I24 product:calpain 2, full insert sequence. AK052141 - Mus musculus 12 days embryo eyeball cDNA, RIKEN full-length enriched library, clone:D230050I17 product:calpain 2, full insert sequence. AK200761 - Mus musculus cDNA, clone:Y1G0135N09, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000027789, based on BLAT search. AK192389 - Mus musculus cDNA, clone:Y1G0108L23, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000027789, based on BLAT search. AK203804 - Mus musculus cDNA, clone:Y1G0146E04, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000027789, based on BLAT search. AK191235 - Mus musculus cDNA, clone:Y1G0105E06, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000027789, based on BLAT search. AF015038 - Mus musculus 80kDa m-calpain subunit (calp80) mRNA, complete cds. AK198770 - Mus musculus cDNA, clone:Y1G0129C07, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000027789, based on BLAT search. AK203361 - Mus musculus cDNA, clone:Y1G0144K06, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000027789, based on BLAT search. AK208163 - Mus musculus cDNA, clone:Y2G0110F03, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000027789, based on BLAT search. AK219579 - Mus musculus cDNA, clone:Y2G0148O11, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000027789, based on BLAT search. AK178489 - Mus musculus cDNA, clone:Y0G0106P03, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000027789, based on BLAT search. AK189547 - Mus musculus cDNA, clone:Y0G0149J03, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000027789, based on BLAT search. AK216791 - Mus musculus cDNA, clone:Y2G0139I06, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000027789, based on BLAT search. AK212305 - Mus musculus cDNA, clone:Y2G0124I06, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000027789, based on BLAT search. Y10139 - M.musculus mRNA for m-calpain. AK183796 - Mus musculus cDNA, clone:Y0G0127E01, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000068505, based on BLAT search. AK207216 - Mus musculus cDNA, clone:Y2G0107E23, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000068505, based on BLAT search. AK183766 - Mus musculus cDNA, clone:Y0G0127B15, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000027789, based on BLAT search. AK183150 - Mus musculus cDNA, clone:Y0G0124N23, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000027789, based on BLAT search. AK195491 - Mus musculus cDNA, clone:Y1G0118K15, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000027789, based on BLAT search. AK199295 - Mus musculus cDNA, clone:Y1G0130M01, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000027789, based on BLAT search. AK182739 - Mus musculus cDNA, clone:Y0G0123J08, strand:unspecified. AK198879 - Mus musculus cDNA, clone:Y1G0129H06, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000064217, based on BLAT search. AK181353 - Mus musculus cDNA, clone:Y0G0117M19, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000027789, based on BLAT search. AK207878 - Mus musculus cDNA, clone:Y2G0109G15, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000027789, based on BLAT search. AK078787 - Mus musculus 15 days embryo male testis cDNA, RIKEN full-length enriched library, clone:8030487N24 product:calpain 2, full insert sequence. AK053832 - Mus musculus 0 day neonate eyeball cDNA, RIKEN full-length enriched library, clone:E130314B09 product:calpain 2, full insert sequence. AK180270 - Mus musculus cDNA, clone:Y0G0113I19, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000068505, based on BLAT search. AK184788 - Mus musculus cDNA, clone:Y0G0131I08, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000068505, based on BLAT search. AK205009 - Mus musculus cDNA, clone:Y1G0150F16, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000068505, based on BLAT search. AK180789 - Mus musculus cDNA, clone:Y0G0115N16, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000068505, based on BLAT search. AK196175 - Mus musculus cDNA, clone:Y1G0121A13, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000068505, based on BLAT search.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu04141 - Protein processing in endoplasmic reticulum mmu04210 - Apoptosis mmu04510 - Focal adhesion mmu05010 - Alzheimer's disease
BioCarta from NCI Cancer Genome Anatomy Project m_mCalpainPathway - mCalpain and friends in Cell motility m_mef2dPathway - Role of MEF2D in T-cell Apoptosis
Reactome (by CSHL, EBI, and GO)
Protein O08529 (Reactome details) participates in the following event(s):
R-MMU-8863416 Calpain 1 or Calpain 2 cleaves Cdk5r1 (p35) R-MMU-8848658 CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins R-MMU-1474228 Degradation of the extracellular matrix R-MMU-1474244 Extracellular matrix organization