The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00375 - Sodium:dicarboxylate symporter family
SCOP Domains: 118215 - Proton glutamate symport protein
ModBase Predicted Comparative 3D Structure on O35544
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006865 amino acid transport GO:0015813 L-glutamate transport GO:0042391 regulation of membrane potential GO:0098712 L-glutamate import across plasma membrane
AK159197 - Mus musculus osteoclast-like cell cDNA, RIKEN full-length enriched library, clone:I420008D08 product:solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6, full insert sequence. D83262 - Mus musculus mRNA for neuronal glutamate transporter EAAT4, complete cds. BC138120 - Mus musculus solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6, mRNA (cDNA clone MGC:169744 IMAGE:8861139), complete cds. BC138140 - Mus musculus solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6, mRNA (cDNA clone MGC:169764 IMAGE:8861159), complete cds.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O35544 (Reactome details) participates in the following event(s):
R-MMU-210404 SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ R-MMU-428015 SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol R-MMU-210500 Glutamate Neurotransmitter Release Cycle R-MMU-425374 Amino acid and oligopeptide SLC transporters R-MMU-425393 Metabolism of nitrogenous molecules R-MMU-112310 Neurotransmitter release cycle R-MMU-425407 SLC-mediated transmembrane transport R-MMU-112315 Transmission across Chemical Synapses R-MMU-382551 Transport of small molecules R-MMU-112316 Neuronal System