Mouse Gene Myf5 (ENSMUST00000000445.1) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus myogenic factor 5 (Myf5), mRNA. (from RefSeq NM_008656)
Gencode Transcript: ENSMUST00000000445.1
Gencode Gene: ENSMUSG00000000435.1
Transcript (Including UTRs)
Position: mm10 chr10:107,482,908-107,486,134 Size: 3,227 Total Exon Count: 3 Strand: -
Coding Region
Position: mm10 chr10:107,484,020-107,485,931 Size: 1,912 Coding Exon Count: 3
Data last updated at UCSC: 2019-09-19
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: MYF5_MOUSE
DESCRIPTION: RecName: Full=Myogenic factor 5; Short=Myf-5;
FUNCTION: Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein.SUBCELLULAR LOCATION: Nucleus.SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR002546 - Basic
IPR011598 - HLH_dom
IPR022032 - Myf5
Pfam Domains: PF00010 - Helix-loop-helix DNA-binding domain
PF01586 - Myogenic Basic domain
PF12232 - Myogenic determination factor 5
SCOP Domains: 47459 - HLH, helix-loop-helix DNA-binding domain
ModBase Predicted Comparative 3D Structure on P24699
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003677 DNA binding
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0043565 sequence-specific DNA binding
GO:0046983 protein dimerization activity
Biological Process: GO:0001502 cartilage condensation
GO:0001503 ossification
GO:0001756 somitogenesis
GO:0001952 regulation of cell-matrix adhesion
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007275 multicellular organism development
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0030154 cell differentiation
GO:0030198 extracellular matrix organization
GO:0035914 skeletal muscle cell differentiation
GO:0043010 camera-type eye development
GO:0045663 positive regulation of myoblast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048644 muscle organ morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048743 positive regulation of skeletal muscle fiber development
GO:0060415 muscle tissue morphogenesis
GO:1901741 positive regulation of myoblast fusion
Cellular Component: GO:0005634 nucleus
GO:0005654 nucleoplasm
Descriptions from all associated GenBank mRNAs
AK083402 - Mus musculus 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030002A18 product:myogenic factor 5, full insert sequence.X56182 - M.musculus myf-5 mRNA.AK044894 - Mus musculus 9.5 days embryo parthenogenote cDNA, RIKEN full-length enriched library, clone:B130010J22 product:myogenic factor 5, full insert sequence.BC132144 - Mus musculus myogenic factor 5, mRNA (cDNA clone MGC:163775 IMAGE:40130421), complete cds.AF336978 - Mus musculus myogenic regulatory factor MYF-5 (Myf5) mRNA, partial cds.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: Myf-5, MYF5_MOUSE, NM_008656, P24699, Q543W7, uc007gyz.1UCSC ID: uc007gyz.1RefSeq Accession: NM_008656
Protein: P24699
(aka MYF5_MOUSE)
CCDS: CCDS24161.1
Gene Model Information
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.