Mouse Gene Dyrk2 (ENSMUST00000004281.9) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (Dyrk2), mRNA. (from RefSeq NM_001014390)
Gencode Transcript: ENSMUST00000004281.9
Gencode Gene: ENSMUSG00000028630.9
Transcript (Including UTRs)
   Position: mm10 chr10:118,855,603-118,869,149 Size: 13,547 Total Exon Count: 3 Strand: -
Coding Region
   Position: mm10 chr10:118,859,552-118,868,769 Size: 9,218 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:118,855,603-118,869,149)mRNA (may differ from genome)Protein (599 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: DYRK2_MOUSE
DESCRIPTION: RecName: Full=Dual specificity tyrosine-phosphorylation-regulated kinase 2; EC=2.7.12.1;
FUNCTION: Serine/threonine-protein kinase involved in the control of mitotic transition and the regulation of cellular growth and/or development. Phosphorylates CRMP4/DPYSL3, EIF2B5, GYS1, p53/TP53, TAU/MAPT, STAT3 and KATNA1. Regulates p53/TP53 by phosphorylation on 'Ser-46' to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at 'Ser- 544', enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of its downstream substrate, KATNA1. Phosphorylation of CRMP4/DPYSL3 promotes its subsequent phosphorylation by GSK3 (By similarity).
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Magnesium (By similarity).
COFACTOR: Manganese (By similarity).
ENZYME REGULATION: Autophosphorylates on tyrosine residues (By similarity).
SUBUNIT: Interacts with MDM2. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and VPRBP proteins (EDVP complex). Interacts directly with EDD/UBR5, DDB1 and VPRBP (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocates into the nucleus following DNA damage (By similarity).
PTM: Phosphorylated on serine/threonine residues (By similarity). Phosphorylation on Thr-104 and Ser-440 by ATM in response to genotoxic stress disrupts MDM2 binding and prevents MDM2-mediated ubiquitination and subsequent proteasome degradation, thus promoting p53/TP53-mediated apoptosis (By similarity).
PTM: Ubiquitination in nucleus by MDM2 in normal conditions leads to proteasome degradation (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
SIMILARITY: Contains 1 protein kinase domain.

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -191.00380-0.503 Picture PostScript Text
3' UTR -1065.903949-0.270 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q5U4C9
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
 RGDEnsemblEnsemblWormBase 
 Protein Sequence Protein SequenceProtein Sequence 
 Alignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0030145 manganese ion binding

Biological Process:
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007224 smoothened signaling pathway
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade

Cellular Component:
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1990904 ribonucleoprotein complex


-  Descriptions from all associated GenBank mRNAs
  LF198251 - JP 2014500723-A/5754: Polycomb-Associated Non-Coding RNAs.
LF224731 - JP 2014500723-A/32234: Polycomb-Associated Non-Coding RNAs.
AK007736 - Mus musculus 10 day old male pancreas cDNA, RIKEN full-length enriched library, clone:1810038L18 product:unclassifiable, full insert sequence.
LF224732 - JP 2014500723-A/32235: Polycomb-Associated Non-Coding RNAs.
AK149371 - Mus musculus adult male liver tumor cDNA, RIKEN full-length enriched library, clone:C730001P21 product:Dual-specificity tyrosine-phosphorylation regulated kinase 2 (EC 2.7.1.-) homolog [Homo sapiens], full insert sequence.
LF224733 - JP 2014500723-A/32236: Polycomb-Associated Non-Coding RNAs.
AK191874 - Mus musculus cDNA, clone:Y1G0107D15, strand:unspecified.
AK200190 - Mus musculus cDNA, clone:Y1G0133L14, strand:unspecified.
BC085145 - Mus musculus dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2, mRNA (cDNA clone MGC:109676 IMAGE:6808145), complete cds.
AK155496 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630307H14 product:Dual-specificity tyrosine-phosphorylation regulated kinase 2 (EC 2.7.1.-) homolog [Homo sapiens], full insert sequence.
LF224734 - JP 2014500723-A/32237: Polycomb-Associated Non-Coding RNAs.
LF224735 - JP 2014500723-A/32238: Polycomb-Associated Non-Coding RNAs.
LF224736 - JP 2014500723-A/32239: Polycomb-Associated Non-Coding RNAs.
LF224737 - JP 2014500723-A/32240: Polycomb-Associated Non-Coding RNAs.
LF224738 - JP 2014500723-A/32241: Polycomb-Associated Non-Coding RNAs.
MA433828 - JP 2018138019-A/5754: Polycomb-Associated Non-Coding RNAs.
MA460308 - JP 2018138019-A/32234: Polycomb-Associated Non-Coding RNAs.
MA460309 - JP 2018138019-A/32235: Polycomb-Associated Non-Coding RNAs.
MA460310 - JP 2018138019-A/32236: Polycomb-Associated Non-Coding RNAs.
MA460311 - JP 2018138019-A/32237: Polycomb-Associated Non-Coding RNAs.
MA460312 - JP 2018138019-A/32238: Polycomb-Associated Non-Coding RNAs.
MA460313 - JP 2018138019-A/32239: Polycomb-Associated Non-Coding RNAs.
MA460314 - JP 2018138019-A/32240: Polycomb-Associated Non-Coding RNAs.
MA460315 - JP 2018138019-A/32241: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q5U4C9 (Reactome details) participates in the following event(s):

R-MMU-6798372 ATM phosphorylates DYRK2
R-MMU-6798373 MDM2 ubiquitinates DYRK2
R-MMU-6798374 DYRK2 phosphorylates TP53
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-5633007 Regulation of TP53 Activity
R-MMU-3700989 Transcriptional Regulation by TP53
R-MMU-212436 Generic Transcription Pathway
R-MMU-73857 RNA Polymerase II Transcription
R-MMU-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: DYRK2_MOUSE, NM_001014390, Q5U4C9, uc007hea.1, uc007hea.2
UCSC ID: uc007hea.2
RefSeq Accession: NM_001014390
Protein: Q5U4C9 (aka DYRK2_MOUSE)
CCDS: CCDS24201.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.