ID:DYRK2_MOUSE DESCRIPTION: RecName: Full=Dual specificity tyrosine-phosphorylation-regulated kinase 2; EC=2.7.12.1; FUNCTION: Serine/threonine-protein kinase involved in the control of mitotic transition and the regulation of cellular growth and/or development. Phosphorylates CRMP4/DPYSL3, EIF2B5, GYS1, p53/TP53, TAU/MAPT, STAT3 and KATNA1. Regulates p53/TP53 by phosphorylation on 'Ser-46' to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at 'Ser- 544', enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of its downstream substrate, KATNA1. Phosphorylation of CRMP4/DPYSL3 promotes its subsequent phosphorylation by GSK3 (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium (By similarity). COFACTOR: Manganese (By similarity). ENZYME REGULATION: Autophosphorylates on tyrosine residues (By similarity). SUBUNIT: Interacts with MDM2. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and VPRBP proteins (EDVP complex). Interacts directly with EDD/UBR5, DDB1 and VPRBP (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocates into the nucleus following DNA damage (By similarity). PTM: Phosphorylated on serine/threonine residues (By similarity). Phosphorylation on Thr-104 and Ser-440 by ATM in response to genotoxic stress disrupts MDM2 binding and prevents MDM2-mediated ubiquitination and subsequent proteasome degradation, thus promoting p53/TP53-mediated apoptosis (By similarity). PTM: Ubiquitination in nucleus by MDM2 in normal conditions leads to proteasome degradation (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF07714 - Protein tyrosine kinase
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on Q5U4C9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006468 protein phosphorylation GO:0006915 apoptotic process GO:0006974 cellular response to DNA damage stimulus GO:0007224 smoothened signaling pathway GO:0016310 phosphorylation GO:0018108 peptidyl-tyrosine phosphorylation GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0045725 positive regulation of glycogen biosynthetic process GO:0070885 negative regulation of calcineurin-NFAT signaling cascade