ID:OS9_MOUSE DESCRIPTION: RecName: Full=Protein OS-9; Flags: Precursor; FUNCTION: Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4 (By similarity). SUBUNIT: Probably part of the HRD1 ubiquitin ligase complex composed at least of SYVN1/HRD1 and SEL1L with which it interacts directly. Through this complex it may interact with ERLEC1 and HSPA5. Interacts with DERL2. Interacts with HSP90B1 and CREB3 (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum lumen (By similarity). PTM: Intramolecular disulfide bonds (By similarity). PTM: N-glycosylated. SIMILARITY: Belongs to the OS-9 family. SIMILARITY: Contains 1 PRKCSH domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8K2C7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006511 ubiquitin-dependent protein catabolic process GO:0006605 protein targeting GO:0006621 protein retention in ER lumen GO:0016567 protein ubiquitination GO:0030433 ER-associated ubiquitin-dependent protein catabolic process GO:0030970 retrograde protein transport, ER to cytosol GO:0034976 response to endoplasmic reticulum stress GO:1904153 negative regulation of retrograde protein transport, ER to cytosol
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu04141 - Protein processing in endoplasmic reticulum
Reactome (by CSHL, EBI, and GO)
Protein Q8K2C7 (Reactome details) participates in the following event(s):
R-MMU-5362437 C-terminal Hh fragments are bound by lectins R-MMU-5362459 VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol R-MMU-1022127 OS9:SEL1:ERAD E3 ligase:DERL2 transports Ub-unfolded protein:(GlcNAc)2 (Man)9-5 from ERQC to cytosol R-MMU-8867288 OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5 R-MMU-5362441 C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane R-MMU-5362412 SYVN1 ubiquitinates Hh C-terminal fragments R-MMU-8866551 CFTR binds components of the ERAD machinery for ubiquitination and degradation R-MMU-8866542 VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol R-MMU-8866546 RNF5 and RNF185 ubiquitinate misfolded CFTR R-MMU-5358346 Hedgehog ligand biogenesis R-MMU-901032 ER Quality Control Compartment (ERQC) R-MMU-382556 ABC-family proteins mediated transport R-MMU-5358351 Signaling by Hedgehog R-MMU-901042 Calnexin/calreticulin cycle R-MMU-382551 Transport of small molecules R-MMU-162582 Signal Transduction R-MMU-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-MMU-446203 Asparagine N-linked glycosylation R-MMU-597592 Post-translational protein modification R-MMU-392499 Metabolism of proteins
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