Mouse Gene Mtmr3 (ENSMUST00000109943.9) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus myotubularin related protein 3 (Mtmr3), mRNA. (from RefSeq NM_028860)
Gencode Transcript: ENSMUST00000109943.9
Gencode Gene: ENSMUSG00000034354.17
Transcript (Including UTRs)
   Position: mm10 chr11:4,480,868-4,594,815 Size: 113,948 Total Exon Count: 18 Strand: -
Coding Region
   Position: mm10 chr11:4,482,768-4,531,224 Size: 48,457 Coding Exon Count: 17 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:4,480,868-4,594,815)mRNA (may differ from genome)Protein (1159 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: B1ATD5_MOUSE
DESCRIPTION: SubName: Full=MCG9626, isoform CRA_b; SubName: Full=Myotubularin related protein 3; SubName: Full=Myotubularin-related protein 3;
SIMILARITY: Contains 1 myotubularin phosphatase domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -162.70294-0.553 Picture PostScript Text
3' UTR -662.401900-0.349 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010569 - Myotub-related
IPR017906 - Myotubularin_phosphatase_dom
IPR016130 - Tyr_Pase_AS
IPR000306 - Znf_FYVE
IPR017455 - Znf_FYVE-rel
IPR011011 - Znf_FYVE_PHD
IPR013083 - Znf_RING/FYVE/PHD

Pfam Domains:
PF01363 - FYVE zinc finger
PF06602 - Myotubularin-like phosphatase domain

SCOP Domains:
50729 - PH domain-like
52799 - (Phosphotyrosine protein) phosphatases II
57903 - FYVE/PHD zinc finger

ModBase Predicted Comparative 3D Structure on B1ATD5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004438 phosphatidylinositol-3-phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0019903 protein phosphatase binding
GO:0046872 metal ion binding
GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity

Biological Process:
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0042149 cellular response to glucose starvation
GO:0046856 phosphatidylinositol dephosphorylation
GO:0060304 regulation of phosphatidylinositol dephosphorylation
GO:1904562 phosphatidylinositol 5-phosphate metabolic process
GO:2000785 regulation of autophagosome assembly

Cellular Component:
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0019898 extrinsic component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC081544 - Mus musculus myotubularin related protein 3, mRNA (cDNA clone MGC:78036 IMAGE:3672099), complete cds.
BC032166 - Mus musculus myotubularin related protein 3, mRNA (cDNA clone MGC:38509 IMAGE:5352919), complete cds.
AK141138 - Mus musculus 0 day neonate cerebellum cDNA, RIKEN full-length enriched library, clone:C230067P07 product:myotubularin related protein 3, full insert sequence.
AK122261 - Mus musculus mRNA for mKIAA0371 protein.
BC026586 - Mus musculus myotubularin related protein 3, mRNA (cDNA clone IMAGE:4972572), partial cds.
AK007036 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:1700092A20 product:myotubularin related protein 3, full insert sequence.
DQ706826 - Mus musculus piRNA piR-122148, complete sequence.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-6367 - D-myo-inositol-5-phosphate metabolism
PWY3DJ-219 - PIP metabolism

Reactome (by CSHL, EBI, and GO)

Protein B1ATD5 (Reactome details) participates in the following event(s):

R-MMU-1675994 PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane
R-MMU-1676203 PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane
R-MMU-5679206 MTMR14, MTMR3 dephosphorylate PI3P
R-MMU-1660499 Synthesis of PIPs at the plasma membrane
R-MMU-1632852 Macroautophagy
R-MMU-1483255 PI Metabolism
R-MMU-8953897 Cellular responses to external stimuli
R-MMU-1483257 Phospholipid metabolism
R-MMU-556833 Metabolism of lipids
R-MMU-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: B1ATD5, B1ATD5_MOUSE, mCG_9626, NM_028860, RP23-173M6.1-002, uc007hux.1
UCSC ID: uc007hux.1
RefSeq Accession: NM_028860
Protein: B1ATD5 CCDS: CCDS48744.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.