Mouse Gene Egfr (ENSMUST00000102884.9) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus epidermal growth factor receptor (Egfr), transcript variant 2, mRNA. (from RefSeq NM_007912)
Gencode Transcript: ENSMUST00000102884.9
Gencode Gene: ENSMUSG00000020122.16
Transcript (Including UTRs)
   Position: mm10 chr11:16,752,203-16,887,923 Size: 135,721 Total Exon Count: 16 Strand: +
Coding Region
   Position: mm10 chr11:16,752,483-16,887,228 Size: 134,746 Coding Exon Count: 16 

Page IndexSequence and LinksPrimersCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:16,752,203-16,887,923)mRNA (may differ from genome)Protein (655 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKBWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -107.60280-0.384 Picture PostScript Text
3' UTR -175.50695-0.253 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000494 - EGF_rcpt_L
IPR006211 - Furin-like_Cys-rich_dom
IPR006212 - Furin_repeat
IPR009030 - Growth_fac_rcpt

Pfam Domains:
PF00757 - Furin-like cysteine rich region
PF01030 - Receptor L domain
PF14843 - Growth factor receptor domain IV

SCOP Domains:
52058 - L domain-like
57184 - Growth factor receptor domain

ModBase Predicted Comparative 3D Structure on Q9WVF5
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding

Biological Process:
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0018108 peptidyl-tyrosine phosphorylation

Cellular Component:
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  AK004883 - Mus musculus adult male liver cDNA, RIKEN full-length enriched library, clone:1300003K07 product:epidermal growth factor receptor, full insert sequence.
AK004944 - Mus musculus adult male liver cDNA, RIKEN full-length enriched library, clone:1300008I23 product:epidermal growth factor receptor, full insert sequence.
AK134262 - Mus musculus 13 days embryo forelimb cDNA, RIKEN full-length enriched library, clone:5930413O06 product:epidermal growth factor receptor, full insert sequence.
AK004911 - Mus musculus adult male liver cDNA, RIKEN full-length enriched library, clone:1300005M11 product:epidermal growth factor receptor, full insert sequence.
BC023729 - Mus musculus epidermal growth factor receptor, mRNA (cDNA clone MGC:36101 IMAGE:5351807), complete cds.
AF124513 - Mus musculus epidermal growth factor receptor (Egfr) mRNA, alternatively spliced, complete cds.
AF275367 - Mus musculus epidermal growth factor receptor (Egfr) mRNA, complete cds.
X59698 - M.musculus mRNA for EGF-receptor.
X78987 - M.musculus (BALB/c) Epidermal Growth Factor Receptor mRNA.
U03425 - Mus musculus B6/C3 EGF receptor mRNA, complete cds.
L06864 - Mus musculus epidermal growth factor receptor (EGFR) mRNA, partial cds.
AK014017 - Mus musculus 13 days embryo head cDNA, RIKEN full-length enriched library, clone:3110007E23 product:EPIDERMAL GROWTH FACTOR RECEPTOR (FRAGMENT) homolog [Mus musculus], full insert sequence.
AK049452 - Mus musculus 7 days embryo whole body cDNA, RIKEN full-length enriched library, clone:C430014G08 product:unclassifiable, full insert sequence.
AF277898 - Mus musculus truncated epidermal growth factor receptor (Egfr) mRNA, partial cds; alternatively spliced.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04010 - MAPK signaling pathway
mmu04012 - ErbB signaling pathway
mmu04020 - Calcium signaling pathway
mmu04060 - Cytokine-cytokine receptor interaction
mmu04144 - Endocytosis
mmu04320 - Dorso-ventral axis formation
mmu04510 - Focal adhesion
mmu04520 - Adherens junction
mmu04540 - Gap junction
mmu04810 - Regulation of actin cytoskeleton
mmu04912 - GnRH signaling pathway
mmu05160 - Hepatitis C
mmu05200 - Pathways in cancer
mmu05212 - Pancreatic cancer
mmu05213 - Endometrial cancer
mmu05214 - Glioma
mmu05215 - Prostate cancer
mmu05218 - Melanoma
mmu05219 - Bladder cancer
mmu05223 - Non-small cell lung cancer

BioCarta from NCI Cancer Genome Anatomy Project
m_ErbB3Pathway - Neuroregulin receptor degredation protein-1 Controls ErbB3 receptor recycling
m_telPathway - Telomeres, Telomerase, Cellular Aging, and Immortality
m_tffPathway - Trefoil Factors Initiate Mucosal Healing
m_cardiacegfPathway - Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy
m_keratinocytePathway - Keratinocyte Differentiation
m_eea1Pathway - The role of FYVE-finger proteins in vesicle transport
m_spryPathway - Sprouty regulation of tyrosine kinase signals
m_egfPathway - EGF Signaling Pathway
m_her2Pathway - Role of ERBB2 in Signal Transduction and Oncology
m_agrPathway - Agrin in Postsynaptic Differentiation
m_egfr_smrtePathway - Map Kinase Inactivation of SMRT Corepressor
m_erkPathway - Erk1/Erk2 Mapk Signaling pathway
m_At1rPathway - Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling
m_cblPathway - CBL mediated ligand-induced downregulation of EGF receptors
m_mCalpainPathway - mCalpain and friends in Cell motility

-  Other Names for This Gene
  Alternate Gene Symbols: mCG_140518, NM_007912, Q5SVE9, Q9WVF5, Q9WVF5_MOUSE, RP23-295E4.1-002, uc007ibn.1, uc007ibn.2
UCSC ID: uc007ibn.2
RefSeq Accession: NM_007912
Protein: Q9WVF5 CCDS: CCDS24444.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.