Mouse Gene Ttc1 (ENSMUST00000048578.2) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus tetratricopeptide repeat domain 1 (Ttc1), mRNA. (from RefSeq NM_133795)
Gencode Transcript: ENSMUST00000048578.2
Gencode Gene: ENSMUSG00000041278.10
Transcript (Including UTRs)
   Position: mm10 chr11:43,730,009-43,747,982 Size: 17,974 Total Exon Count: 8 Strand: -
Coding Region
   Position: mm10 chr11:43,730,474-43,745,414 Size: 14,941 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:43,730,009-43,747,982)mRNA (may differ from genome)Protein (292 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: TTC1_MOUSE
DESCRIPTION: RecName: Full=Tetratricopeptide repeat protein 1; Short=TPR repeat protein 1;
SUBUNIT: Interacts with the GAP domain of NF1 (By similarity).
SIMILARITY: Contains 3 TPR repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -37.5094-0.399 Picture PostScript Text
3' UTR -139.40465-0.300 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023114 - Elongated_TPR_rpt_dom
IPR001440 - TPR-1
IPR013026 - TPR-contain_dom
IPR011990 - TPR-like_helical
IPR019734 - TPR_repeat

Pfam Domains:
PF13174 - Tetratricopeptide repeat
PF13181 - Tetratricopeptide repeat

SCOP Domains:
81901 - HCP-like
48439 - Protein prenylyltransferase
48452 - TPR-like
116846 - MIT domain

ModBase Predicted Comparative 3D Structure on Q91Z38
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsemblEnsemblWormBase 
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AK077715 - Mus musculus 8 days embryo whole body cDNA, RIKEN full-length enriched library, clone:5730547M21 product:SIMILAR TO TETRATRICOPEPTIDE REPEAT DOMAIN 1, full insert sequence.
AK166431 - Mus musculus mammary gland RCB-0527 Jyg-MC(B) cDNA, RIKEN full-length enriched library, clone:G930017N08 product:tetratricopeptide repeat domain 1, full insert sequence.
BC010236 - Mus musculus tetratricopeptide repeat domain 1, mRNA (cDNA clone MGC:7871 IMAGE:3581904), complete cds.
AK170032 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630011A06 product:tetratricopeptide repeat domain 1, full insert sequence.
AK170230 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630034G09 product:tetratricopeptide repeat domain 1, full insert sequence.
AK019021 - Mus musculus 10 day old male pancreas cDNA, RIKEN full-length enriched library, clone:1810021M18 product:SIMILAR TO TETRATRICOPEPTIDE REPEAT DOMAIN 1, full insert sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_133795, Q3TLM0, Q91Z38, TTC1_MOUSE, uc007imx.1, uc007imx.2
UCSC ID: uc007imx.2
RefSeq Accession: NM_133795
Protein: Q91Z38 (aka TTC1_MOUSE)
CCDS: CCDS24561.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.