The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P39655
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004052 arachidonate 12-lipoxygenase activity GO:0005506 iron ion binding GO:0016165 linoleate 13S-lipoxygenase activity GO:0016491 oxidoreductase activity GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0016787 hydrolase activity GO:0046872 metal ion binding GO:0047977 hepoxilin-epoxide hydrolase activity GO:0051213 dioxygenase activity
Biological Process: GO:0006629 lipid metabolic process GO:0006631 fatty acid metabolic process GO:0007568 aging GO:0008284 positive regulation of cell proliferation GO:0010595 positive regulation of endothelial cell migration GO:0010628 positive regulation of gene expression GO:0010656 negative regulation of muscle cell apoptotic process GO:0010942 positive regulation of cell death GO:0019369 arachidonic acid metabolic process GO:0019372 lipoxygenase pathway GO:0019395 fatty acid oxidation GO:0043065 positive regulation of apoptotic process GO:0043066 negative regulation of apoptotic process GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043651 linoleic acid metabolic process GO:0045603 positive regulation of endothelial cell differentiation GO:0048661 positive regulation of smooth muscle cell proliferation GO:0051122 hepoxilin biosynthetic process GO:0051901 positive regulation of mitochondrial depolarization GO:0055114 oxidation-reduction process GO:0061436 establishment of skin barrier GO:0071396 cellular response to lipid GO:0090331 negative regulation of platelet aggregation GO:1901751 leukotriene A4 metabolic process GO:2001303 lipoxin A4 biosynthetic process GO:2001306 lipoxin B4 biosynthetic process
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu00590 - Arachidonic acid metabolism mmu01100 - Metabolic pathways
Reactome (by CSHL, EBI, and GO)
Protein P39655 (Reactome details) participates in the following event(s):
R-MMU-2161775 LTA4 is converted to LXA4/B4 by ALOX12 R-MMU-9020274 ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA R-MMU-2161794 Arachidonic acid is converted to HXA3/B3 by ALOX12 R-MMU-2161948 Arachidonic acid is converted to 12-oxoETE by ALOX12 R-MMU-9024983 ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA R-MMU-9025957 ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 R-MMU-9026006 ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 R-MMU-9026007 ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 R-MMU-2161964 Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 R-MMU-2142700 Synthesis of Lipoxins (LX) R-MMU-9018677 Biosynthesis of DHA-derived SPMs R-MMU-2142696 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) R-MMU-2142712 Synthesis of 12-eicosatetraenoic acid derivatives R-MMU-9025106 Biosynthesis of DPAn-6 SPMs R-MMU-9026290 Biosynthesis of DPAn-3-derived maresins R-MMU-9018678 Biosynthesis of specialized proresolving mediators (SPMs) R-MMU-2142753 Arachidonic acid metabolism R-MMU-9018683 Biosynthesis of DPA-derived SPMs R-MMU-9025094 Biosynthesis of DPAn-3 SPMs R-MMU-8978868 Fatty acid metabolism R-MMU-556833 Metabolism of lipids R-MMU-1430728 Metabolism
US Server
