Mouse Gene Dnajc7 (ENSMUST00000014339.14) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus DnaJ heat shock protein family (Hsp40) member C7 (Dnajc7), mRNA. (from RefSeq NM_019795)
Gencode Transcript: ENSMUST00000014339.14
Gencode Gene: ENSMUSG00000014195.15
Transcript (Including UTRs)
   Position: mm10 chr11:100,582,818-100,620,168 Size: 37,351 Total Exon Count: 14 Strand: -
Coding Region
   Position: mm10 chr11:100,583,099-100,619,604 Size: 36,506 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:100,582,818-100,620,168)mRNA (may differ from genome)Protein (494 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: DNJC7_MOUSE
DESCRIPTION: RecName: Full=DnaJ homolog subfamily C member 7; AltName: Full=Cytoplasmic CAR retention protein; Short=CCRP; AltName: Full=MDj11; AltName: Full=Tetratricopeptide repeat protein 2; Short=TPR repeat protein 2;
FUNCTION: Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone- substrate complexes (By similarity). Recruits NR1I3 to the cytoplasm.
SUBUNIT: Associates with complexes containing chaperones HSP70 and HSP90. Interacts with the GAP domain of NF1. Interacts with HSP90AA1. Interacts with HSPA1A/B; the interaction is enhanced by ATP. Interacts with HSP90AB1. Interacts with PGR. Interacts with RAD9A; the interaction is interrupted by UV and heat shock treatments. Interacts with HUS1 and RAD1 (By similarity). Interacts with NR1I3; this complex may also include HSP90 Interacts with HSPA8 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm. Nucleus (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Colocalizes with NR1I3 at microtubules (By similarity).
TISSUE SPECIFICITY: Widely expressed with high levels in liver, skeletal muscle, kidney and testis.
SIMILARITY: Contains 1 J domain.
SIMILARITY: Contains 9 TPR repeats.

-  Primer design for this transcript
 

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Click here to open Exonprimer with this transcript

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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -236.50564-0.419 Picture PostScript Text
3' UTR -68.70281-0.244 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001623 - DnaJ_N
IPR023114 - Elongated_TPR_rpt_dom
IPR003095 - Hsp_DnaJ
IPR001440 - TPR-1
IPR013026 - TPR-contain_dom
IPR011990 - TPR-like_helical
IPR019734 - TPR_repeat

Pfam Domains:
PF00226 - DnaJ domain
PF07719 - Tetratricopeptide repeat
PF08238 - Sel1 repeat
PF13181 - Tetratricopeptide repeat
PF13414 - TPR repeat
PF13431 - Tetratricopeptide repeat
PF13432 - Tetratricopeptide repeat

SCOP Domains:
81901 - HCP-like
48439 - Protein prenylyltransferase
48452 - TPR-like
46565 - Chaperone J-domain
116846 - MIT domain
140361 - MIT domain-like
158372 - AF1782-like
55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain
144059 - ImpE-like

ModBase Predicted Comparative 3D Structure on Q9QYI3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsemblEnsembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0031072 heat shock protein binding

Biological Process:
GO:0051085 chaperone mediated protein folding requiring cofactor

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton


-  Descriptions from all associated GenBank mRNAs
  LF198876 - JP 2014500723-A/6379: Polycomb-Associated Non-Coding RNAs.
AK145739 - Mus musculus blastocyst blastocyst cDNA, RIKEN full-length enriched library, clone:I1C0036L01 product:DnaJ (Hsp40) homolog, subfamily C, member 7, full insert sequence.
BC023681 - Mus musculus DnaJ (Hsp40) homolog, subfamily C, member 7, mRNA (cDNA clone MGC:35912 IMAGE:5343384), complete cds.
BC055729 - Mus musculus DnaJ (Hsp40) homolog, subfamily C, member 7, mRNA (cDNA clone MGC:66940 IMAGE:6414499), complete cds.
AK011384 - Mus musculus 10 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2610011N24 product:DnaJ (Hsp40) homolog, subfamily C, member 7, full insert sequence.
AK008029 - Mus musculus adult male small intestine cDNA, RIKEN full-length enriched library, clone:2010002A22 product:DnaJ (Hsp40) homolog, subfamily C, member 7, full insert sequence.
AK008092 - Mus musculus adult male small intestine cDNA, RIKEN full-length enriched library, clone:2010004G07 product:DnaJ (Hsp40) homolog, subfamily C, member 7, full insert sequence.
AK008268 - Mus musculus adult male small intestine cDNA, RIKEN full-length enriched library, clone:2010016C15 product:DnaJ (Hsp40) homolog, subfamily C, member 7, full insert sequence.
AK011875 - Mus musculus 10 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2610204E12 product:DnaJ (Hsp40) homolog, subfamily C, member 7, full insert sequence.
AB028861 - Mus musculus mRNA for mDj11, complete cds.
AK145506 - Mus musculus blastocyst blastocyst cDNA, RIKEN full-length enriched library, clone:I1C0008D16 product:DnaJ (Hsp40) homolog, subfamily C, member 7, full insert sequence.
AK166872 - Mus musculus blastocyst blastocyst cDNA, RIKEN full-length enriched library, clone:I1C0019J20 product:DnaJ (Hsp40) homolog, subfamily C, member 7, full insert sequence.
AK076032 - Mus musculus 10 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2610300C22 product:DnaJ (Hsp40) homolog, subfamily C, member 7, full insert sequence.
LF230513 - JP 2014500723-A/38016: Polycomb-Associated Non-Coding RNAs.
LF230514 - JP 2014500723-A/38017: Polycomb-Associated Non-Coding RNAs.
AY323828 - Mus musculus cytoplasmic CAR retention protein mRNA, complete cds.
LF230516 - JP 2014500723-A/38019: Polycomb-Associated Non-Coding RNAs.
LF230517 - JP 2014500723-A/38020: Polycomb-Associated Non-Coding RNAs.
AK208545 - Mus musculus cDNA, clone:Y2G0111O12, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014339, based on BLAT search.
LF230518 - JP 2014500723-A/38021: Polycomb-Associated Non-Coding RNAs.
LF230519 - JP 2014500723-A/38022: Polycomb-Associated Non-Coding RNAs.
LF230521 - JP 2014500723-A/38024: Polycomb-Associated Non-Coding RNAs.
AK177645 - Mus musculus cDNA, clone:Y0G0103I22, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000014339, based on BLAT search.
LF230522 - JP 2014500723-A/38025: Polycomb-Associated Non-Coding RNAs.
LF230529 - JP 2014500723-A/38032: Polycomb-Associated Non-Coding RNAs.
LF230546 - JP 2014500723-A/38049: Polycomb-Associated Non-Coding RNAs.
LF230547 - JP 2014500723-A/38050: Polycomb-Associated Non-Coding RNAs.
MA434453 - JP 2018138019-A/6379: Polycomb-Associated Non-Coding RNAs.
MA466090 - JP 2018138019-A/38016: Polycomb-Associated Non-Coding RNAs.
MA466091 - JP 2018138019-A/38017: Polycomb-Associated Non-Coding RNAs.
MA466093 - JP 2018138019-A/38019: Polycomb-Associated Non-Coding RNAs.
MA466094 - JP 2018138019-A/38020: Polycomb-Associated Non-Coding RNAs.
MA466095 - JP 2018138019-A/38021: Polycomb-Associated Non-Coding RNAs.
MA466096 - JP 2018138019-A/38022: Polycomb-Associated Non-Coding RNAs.
MA466098 - JP 2018138019-A/38024: Polycomb-Associated Non-Coding RNAs.
MA466099 - JP 2018138019-A/38025: Polycomb-Associated Non-Coding RNAs.
MA466106 - JP 2018138019-A/38032: Polycomb-Associated Non-Coding RNAs.
MA466123 - JP 2018138019-A/38049: Polycomb-Associated Non-Coding RNAs.
MA466124 - JP 2018138019-A/38050: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9QYI3 (Reactome details) participates in the following event(s):

R-MMU-5251955 HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm
R-MMU-5251959 HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol
R-MMU-3371453 Regulation of HSF1-mediated heat shock response
R-MMU-3371556 Cellular response to heat stress
R-MMU-2262752 Cellular responses to stress
R-MMU-8953897 Cellular responses to external stimuli

-  Other Names for This Gene
  Alternate Gene Symbols: DNJC7_MOUSE, NM_019795, Q3TKR1, Q6VVW6, Q8BPG3, Q8CIL2, Q9CT29, Q9D026, Q9QYI3, Ttc2, uc007lls.1, uc007lls.2
UCSC ID: uc007lls.2
RefSeq Accession: NM_019795
Protein: Q9QYI3 (aka DNJC7_MOUSE or DJC7_MOUSE)
CCDS: CCDS25428.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.