ID:DNJC7_MOUSE DESCRIPTION: RecName: Full=DnaJ homolog subfamily C member 7; AltName: Full=Cytoplasmic CAR retention protein; Short=CCRP; AltName: Full=MDj11; AltName: Full=Tetratricopeptide repeat protein 2; Short=TPR repeat protein 2; FUNCTION: Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone- substrate complexes (By similarity). Recruits NR1I3 to the cytoplasm. SUBUNIT: Associates with complexes containing chaperones HSP70 and HSP90. Interacts with the GAP domain of NF1. Interacts with HSP90AA1. Interacts with HSPA1A/B; the interaction is enhanced by ATP. Interacts with HSP90AB1. Interacts with PGR. Interacts with RAD9A; the interaction is interrupted by UV and heat shock treatments. Interacts with HUS1 and RAD1 (By similarity). Interacts with NR1I3; this complex may also include HSP90 Interacts with HSPA8 (By similarity). SUBCELLULAR LOCATION: Cytoplasm. Nucleus (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Colocalizes with NR1I3 at microtubules (By similarity). TISSUE SPECIFICITY: Widely expressed with high levels in liver, skeletal muscle, kidney and testis. SIMILARITY: Contains 1 J domain. SIMILARITY: Contains 9 TPR repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9QYI3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein Q9QYI3 (Reactome details) participates in the following event(s):
R-MMU-5251955 HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm R-MMU-5251959 HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol R-MMU-3371453 Regulation of HSF1-mediated heat shock response R-MMU-3371556 Cellular response to heat stress R-MMU-2262752 Cellular responses to stress R-MMU-8953897 Cellular responses to external stimuli