Mouse Gene Smc6 (ENSMUST00000218866.1) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity). (from UniProt Q924W5) Gencode Transcript: ENSMUST00000218866.1 Gencode Gene: ENSMUSG00000020608.7 Transcript (Including UTRs) Position: mm10 chr12:11,266,129-11,287,654 Size: 21,526 Total Exon Count: 10 Strand: + Coding Region Position: mm10 chr12:11,271,734-11,285,427 Size: 13,694 Coding Exon Count: 9
ID:SMC6_MOUSE DESCRIPTION: RecName: Full=Structural maintenance of chromosomes protein 6; Short=SMC protein 6; Short=SMC-6; Short=mSMC6; FUNCTION: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity). SUBUNIT: Forms a heterodimer with SMC5. Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2 (By similarity). SUBCELLULAR LOCATION: Nucleus. Chromosome. Chromosome, telomere (By similarity). Note=Associates with chromatin. DOMAIN: The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC5, forming a V- shaped heterodimer (By similarity). PTM: Phosphorylated (By similarity). PTM: Sumoylated by NSMCE2/MMS21 (By similarity). PTM: Ubiquitinated (By similarity). SIMILARITY: Belongs to the SMC family. SMC6 subfamily. SEQUENCE CAUTION: Sequence=BAB23051.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q924W5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.