Mouse Gene Hpcal1 (ENSMUST00000071858.4) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus hippocalcin-like 1 (Hpcal1), transcript variant 1, mRNA. (from RefSeq NM_016677)
Gencode Transcript: ENSMUST00000071858.4
Gencode Gene: ENSMUSG00000071379.2
Transcript (Including UTRs)
   Position: mm10 chr12:17,690,856-17,791,933 Size: 101,078 Total Exon Count: 4 Strand: +
Coding Region
   Position: mm10 chr12:17,786,171-17,791,204 Size: 5,034 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:17,690,856-17,791,933)mRNA (may differ from genome)Protein (193 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: HPCL1_MOUSE
DESCRIPTION: RecName: Full=Hippocalcin-like protein 1; AltName: Full=Neural visinin-like protein 3; Short=NVL-3; Short=NVP-3; AltName: Full=Visinin-like protein 3; Short=VILIP-3;
FUNCTION: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.
MISCELLANEOUS: Probably binds two or three calcium ions (By similarity).
SIMILARITY: Belongs to the recoverin family.
SIMILARITY: Contains 4 EF-hand domains.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -87.90215-0.409 Picture PostScript Text
3' UTR -208.40729-0.286 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018248 - EF-hand
IPR011992 - EF-hand-like_dom
IPR018247 - EF_Hand_1_Ca_BS
IPR018249 - EF_HAND_2
IPR002048 - EF_hand_Ca-bd
IPR001125 - Recoverin

Pfam Domains:
PF00036 - EF hand
PF13202 - EF hand
PF13405 - EF-hand domain
PF13499 - EF-hand domain pair
PF13833 - EF-hand domain pair

SCOP Domains:
63446 - Type I dockerin domain
47473 - EF-hand

ModBase Predicted Comparative 3D Structure on P62748
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
 RGDEnsemblEnsembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  BC001997 - Mus musculus hippocalcin-like 1, mRNA (cDNA clone MGC:5754 IMAGE:3496729), complete cds.
AK002849 - Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:0610039M24 product:hippocalcin-like 1, full insert sequence.
AK189004 - Mus musculus cDNA, clone:Y0G0147F09, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000045465, based on BLAT search.
AF085192 - Mus musculus neural visinin-like protein 3 (NVP-3) mRNA, complete cds.
AK215724 - Mus musculus cDNA, clone:Y2G0135P22, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000052439, based on BLAT search.
AK181174 - Mus musculus cDNA, clone:Y0G0117D04, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000052439, based on BLAT search.
AK182666 - Mus musculus cDNA, clone:Y0G0123F20, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000052439, based on BLAT search.
AK213639 - Mus musculus cDNA, clone:Y2G0128P08, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000052439, based on BLAT search.
AK220058 - Mus musculus cDNA, clone:Y2G0150K09, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000052439, based on BLAT search.
AK184538 - Mus musculus cDNA, clone:Y0G0130I10, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000052439, based on BLAT search.
AK183803 - Mus musculus cDNA, clone:Y0G0127E14, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000052439, based on BLAT search.
AK179780 - Mus musculus cDNA, clone:Y0G0111K21, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000052439, based on BLAT search.
AK185469 - Mus musculus cDNA, clone:Y0G0134C16, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000052439, based on BLAT search.
AK182612 - Mus musculus cDNA, clone:Y0G0123C24, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000052439, based on BLAT search.
AK179918 - Mus musculus cDNA, clone:Y0G0112C22, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000052439, based on BLAT search.
AK182967 - Mus musculus cDNA, clone:Y0G0124E23, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000052439, based on BLAT search.
AK187818 - Mus musculus cDNA, clone:Y0G0143C11, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000052439, based on BLAT search.
AK210795 - Mus musculus cDNA, clone:Y2G0119K01, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000052439, based on BLAT search.
AK189100 - Mus musculus cDNA, clone:Y0G0147N03, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000052439, based on BLAT search.

-  Other Names for This Gene
  Alternate Gene Symbols: HPCL1_MOUSE, NM_016677, P35333, P62748, uc007ncx.1, uc007ncx.2
UCSC ID: uc007ncx.2
RefSeq Accession: NM_016677
Protein: P62748 (aka HPCL1_MOUSE or HPC1_MOUSE)
CCDS: CCDS25830.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.