Mouse Gene Dmac2l (ENSMUST00000021372.5) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus distal membrane arm assembly complex 2 like (Dmac2l), transcript variant 1, mRNA. (from RefSeq NM_026536)
Gencode Transcript: ENSMUST00000021372.5
Gencode Gene: ENSMUSG00000054894.6
Transcript (Including UTRs)
   Position: mm10 chr12:69,724,962-69,744,658 Size: 19,697 Total Exon Count: 5 Strand: +
Coding Region
   Position: mm10 chr12:69,737,955-69,743,833 Size: 5,879 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:69,724,962-69,744,658)mRNA (may differ from genome)Protein (200 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: ATP5S_MOUSE
DESCRIPTION: RecName: Full=ATP synthase subunit s, mitochondrial; AltName: Full=ATP synthase-coupling factor B; AltName: Full=Mitochondrial ATP synthase regulatory component factor B; Flags: Precursor;
FUNCTION: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.
SUBUNIT: Homotetramer. Associates with ATP synthase (By similarity).
SUBCELLULAR LOCATION: Mitochondrion (By similarity). Mitochondrion inner membrane (By similarity).
SIMILARITY: Belongs to the ATP synthase subunit s family.
SIMILARITY: Contains 4 LRR (leucine-rich) repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -13.0057-0.228 Picture PostScript Text
3' UTR -175.60825-0.213 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026063 - ATP_synthase_s

SCOP Domains:
52047 - RNI-like
52058 - L domain-like
52075 - Outer arm dynein light chain 1
56502 - gp120 core

ModBase Predicted Comparative 3D Structure on Q9CRA7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsemblEnsemblWormBase 
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0046872 metal ion binding

Biological Process:
GO:0006754 ATP biosynthetic process
GO:0006811 ion transport

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)


-  Descriptions from all associated GenBank mRNAs
  AK009141 - Mus musculus adult male tongue cDNA, RIKEN full-length enriched library, clone:2310004I07 product:similar to MITOCHONDRIAL ATP SYNTHASE REGULATORY COMPONENT FACTOR B [Homo sapiens], full insert sequence.
AK003725 - Mus musculus 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110015E18 product:similar to MITOCHONDRIAL ATP SYNTHASE REGULATORY COMPONENT FACTOR B [Homo sapiens], full insert sequence.
BC027442 - Mus musculus ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s, mRNA (cDNA clone MGC:35642 IMAGE:4015414), complete cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9CRA7 (Reactome details) participates in the following event(s):

R-MMU-164840 ADP and Pi bind to ATPase
R-MMU-8949580 F1Fo ATP synthase dimerizes
R-MMU-164834 Enzyme-bound ATP is released
R-MMU-164832 ATPase synthesizes ATP
R-MMU-163210 Formation of ATP by chemiosmotic coupling
R-MMU-8949613 Cristae formation
R-MMU-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
R-MMU-1592230 Mitochondrial biogenesis
R-MMU-1428517 The citric acid (TCA) cycle and respiratory electron transport
R-MMU-1852241 Organelle biogenesis and maintenance
R-MMU-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: Atp5s, ATP5S_MOUSE, Atpw, NM_026536, Q8R2M3, Q9CRA7, uc007nsr.1
UCSC ID: uc007nsr.1
RefSeq Accession: NM_026536
Protein: Q9CRA7 (aka ATP5S_MOUSE or ATPW_MOUSE)
CCDS: CCDS25954.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.