ID:ATP5S_MOUSE DESCRIPTION: RecName: Full=ATP synthase subunit s, mitochondrial; AltName: Full=ATP synthase-coupling factor B; AltName: Full=Mitochondrial ATP synthase regulatory component factor B; Flags: Precursor; FUNCTION: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway. SUBUNIT: Homotetramer. Associates with ATP synthase (By similarity). SUBCELLULAR LOCATION: Mitochondrion (By similarity). Mitochondrion inner membrane (By similarity). SIMILARITY: Belongs to the ATP synthase subunit s family. SIMILARITY: Contains 4 LRR (leucine-rich) repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9CRA7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK009141 - Mus musculus adult male tongue cDNA, RIKEN full-length enriched library, clone:2310004I07 product:similar to MITOCHONDRIAL ATP SYNTHASE REGULATORY COMPONENT FACTOR B [Homo sapiens], full insert sequence. AK003725 - Mus musculus 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110015E18 product:similar to MITOCHONDRIAL ATP SYNTHASE REGULATORY COMPONENT FACTOR B [Homo sapiens], full insert sequence. BC027442 - Mus musculus ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s, mRNA (cDNA clone MGC:35642 IMAGE:4015414), complete cds.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9CRA7 (Reactome details) participates in the following event(s):
R-MMU-164840 ADP and Pi bind to ATPase R-MMU-8949580 F1Fo ATP synthase dimerizes R-MMU-164834 Enzyme-bound ATP is released R-MMU-164832 ATPase synthesizes ATP R-MMU-163210 Formation of ATP by chemiosmotic coupling R-MMU-8949613 Cristae formation R-MMU-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-MMU-1592230 Mitochondrial biogenesis R-MMU-1428517 The citric acid (TCA) cycle and respiratory electron transport R-MMU-1852241 Organelle biogenesis and maintenance R-MMU-1430728 Metabolism