Mouse Gene Jkamp (ENSMUST00000057257.9) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus JNK1/MAPK8-associated membrane protein (Jkamp), transcript variant 1, mRNA. (from RefSeq NM_024205)
Gencode Transcript: ENSMUST00000057257.9
Gencode Gene: ENSMUSG00000005078.16
Transcript (Including UTRs)
   Position: mm10 chr12:72,085,857-72,100,861 Size: 15,005 Total Exon Count: 7 Strand: +
Coding Region
   Position: mm10 chr12:72,086,180-72,100,828 Size: 14,649 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:72,085,857-72,100,861)mRNA (may differ from genome)Protein (311 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: JKAMP_MOUSE
DESCRIPTION: RecName: Full=JNK1/MAPK8-associated membrane protein; Short=JKAMP; AltName: Full=JNK1-associated membrane protein; Short=JAMP; AltName: Full=Medulloblastoma antigen MU-MB-50.4 homolog;
FUNCTION: May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system.
SUBUNIT: Interacts with RNF5 and MAPK8, but not with MAPK9. Binding to MAPK8 occurs before and after exposure to stress, such as UV irradiation. After exposure to stress, interacts with phosphorylated MAPK8. Competes with DUSP10 for MAPK8 binding. Associates with multiple components of the proteasome and with ERAD regulatory proteins, including AMFR/GP78, CANX, PSMC1, PSMC2, PSMC3/TBP1, PSMC5, PSMC6, PSMD8, SEC61-ALPHA and UFD1L.
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in numerous tissues, including brain, spleen, thymus, liver, kidney and testis. Elevated expression in medulloblastoma.
INDUCTION: By ER stress.
PTM: Ubiquitinated by RNF5 via 'Lys-63'-linked ubiquitin linkage in a UBE2N-dependent manner. Ubiquitination decreases association with components of the proteasome and ERAD.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -131.30323-0.407 Picture PostScript Text
3' UTR 0.00330.000 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008485 - DUF766

Pfam Domains:
PF05571 - Protein of unknown function (DUF766)

ModBase Predicted Comparative 3D Structure on Q8BI36
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsemblEnsemblWormBase 
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0031625 ubiquitin protein ligase binding

Biological Process:
GO:0006986 response to unfolded protein
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process

Cellular Component:
GO:0005575 cellular_component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK004555 - Mus musculus adult male lung cDNA, RIKEN full-length enriched library, clone:1200003C05 product:SIMILAR TO HYPOTHETICAL PROTEIN homolog [Mus musculus], full insert sequence.
BC002238 - Mus musculus RIKEN cDNA 1200003C05 gene, mRNA (cDNA clone MGC:7519 IMAGE:3491879), complete cds.
AK009884 - Mus musculus adult male tongue cDNA, RIKEN full-length enriched library, clone:2310047L11 product:unclassifiable, full insert sequence.
AK013502 - Mus musculus adult male hippocampus cDNA, RIKEN full-length enriched library, clone:2900009D01 product:inferred: RIKEN cDNA 1200003C05 gene / Similar to hypothetical protein [Mus musculus], full insert sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: B8JJ79, B8JJ80, Jamp, JKAMP_MOUSE, NM_024205, Q8BI36, Q99LT2, Q9CUZ1, uc007nvf.1, uc007nvf.2, uc007nvf.3
UCSC ID: uc007nvf.3
RefSeq Accession: NM_024205
Protein: Q8BI36 (aka JKAMP_MOUSE)
CCDS: CCDS25967.1, CCDS56844.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.