ID:GEPH_MOUSE DESCRIPTION: RecName: Full=Gephyrin; Includes: RecName: Full=Molybdopterin adenylyltransferase; Short=MPT adenylyltransferase; EC=2.7.7.75; AltName: Full=Domain G; Includes: RecName: Full=Molybdopterin molybdenumtransferase; Short=MPT Mo-transferase; EC=2.10.1.1; AltName: Full=Domain E; FUNCTION: Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. CATALYTIC ACTIVITY: ATP + molybdopterin = diphosphate + adenylyl- molybdopterin. CATALYTIC ACTIVITY: Adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP. COFACTOR: Magnesium (By similarity). ENZYME REGULATION: Inhibited by copper and tungsten (By similarity). PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis. SUBUNIT: Homotrimer, homodimer and homooligomer. Interacts with GLRB and GABARAP (By similarity). Interacts with SRGAP2 (via SH3 domain). SUBCELLULAR LOCATION: Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Cytoplasmic face of glycinergic postsynaptic membranes (By similarity). SIMILARITY: In the N-terminal section; belongs to the MoaB/Mog family. SIMILARITY: In the C-terminal section; belongs to the MoeA family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8BUV3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006777 Mo-molybdopterin cofactor biosynthetic process GO:0007529 establishment of synaptic specificity at neuromuscular junction GO:0008152 metabolic process GO:0010038 response to metal ion GO:0018315 molybdenum incorporation into molybdenum-molybdopterin complex GO:0032324 molybdopterin cofactor biosynthetic process GO:0045184 establishment of protein localization GO:0051260 protein homooligomerization GO:0055114 oxidation-reduction process GO:0072579 glycine receptor clustering GO:0097112 gamma-aminobutyric acid receptor clustering GO:0098880 maintenance of postsynaptic specialization structure GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping
US Server
