The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q3UYK2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0002265 astrocyte activation involved in immune response GO:0003407 neural retina development GO:0006508 proteolysis GO:0006509 membrane protein ectodomain proteolysis GO:0007219 Notch signaling pathway GO:0007611 learning or memory GO:0007613 memory GO:0016485 protein processing GO:0032092 positive regulation of protein binding GO:0032469 endoplasmic reticulum calcium ion homeostasis GO:0033160 positive regulation of protein import into nucleus, translocation GO:0034205 beta-amyloid formation GO:0035556 intracellular signal transduction GO:0042325 regulation of phosphorylation GO:0042327 positive regulation of phosphorylation GO:0042982 amyloid precursor protein metabolic process GO:0042987 amyloid precursor protein catabolic process GO:0043066 negative regulation of apoptotic process GO:0043085 positive regulation of catalytic activity GO:0043524 negative regulation of neuron apoptotic process GO:0045893 positive regulation of transcription, DNA-templated GO:0048143 astrocyte activation GO:0050808 synapse organization GO:0060999 positive regulation of dendritic spine development GO:0070588 calcium ion transmembrane transport GO:0090647 modulation of age-related behavioral decline GO:0098609 cell-cell adhesion GO:1904646 cellular response to beta-amyloid GO:1904797 negative regulation of core promoter binding GO:1990535 neuron projection maintenance
BioCarta from NCI Cancer Genome Anatomy Project m_erbB4pathway - g-Secretase mediated ErbB4 Signaling Pathway m_HivnefPathway - HIV-I Nef: negative effector of Fas and TNF m_notchpathway - Proteolysis and Signaling Pathway of Notch m_ps1Pathway - Presenilin action in Notch and Wnt signaling m_appPathway - Generation of amyloid b-peptide by PS1
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