Mouse Gene Sptlc2 (ENSMUST00000021424.4) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus serine palmitoyltransferase, long chain base subunit 2 (Sptlc2), mRNA. (from RefSeq NM_011479) RefSeq Summary (NM_011479): This gene encodes a long chain base subunit of serine palmitoyltransferase. The enzyme, serine palmitoyltransferase, consists of two different subunits, and is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. A mutant allele of this gene in mice is used as a model for the human disease 'Susceptibilty to Psoriasis 1'. Mutations in the human gene are associated with hereditary sensory neuropathy type I. [provided by RefSeq, Sep 2015]. Gencode Transcript: ENSMUST00000021424.4 Gencode Gene: ENSMUSG00000021036.10 Transcript (Including UTRs) Position: mm10 chr12:87,305,058-87,388,355 Size: 83,298 Total Exon Count: 12 Strand: - Coding Region Position: mm10 chr12:87,309,901-87,388,171 Size: 78,271 Coding Exon Count: 12
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q542D6
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006686 sphingomyelin biosynthetic process GO:0008152 metabolic process GO:0009058 biosynthetic process GO:0030148 sphingolipid biosynthetic process GO:0046511 sphinganine biosynthetic process GO:0046512 sphingosine biosynthetic process GO:0046513 ceramide biosynthetic process GO:1904504 positive regulation of lipophagy
US Server
