Mouse Gene Adck1 (ENSMUST00000101165.8) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus aarF domain containing kinase 1 (Adck1), transcript variant 2, mRNA. (from RefSeq NM_001277297)
Gencode Transcript: ENSMUST00000101165.8
Gencode Gene: ENSMUSG00000021044.15
Transcript (Including UTRs)
   Position: mm10 chr12:88,360,554-88,461,719 Size: 101,166 Total Exon Count: 11 Strand: +
Coding Region
   Position: mm10 chr12:88,368,346-88,461,192 Size: 92,847 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:88,360,554-88,461,719)mRNA (may differ from genome)Protein (525 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ADCK1_MOUSE
DESCRIPTION: RecName: Full=Uncharacterized aarF domain-containing protein kinase 1; EC=2.7.11.-; Flags: Precursor;
FUNCTION: The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).
SUBCELLULAR LOCATION: Secreted (Potential).
SIMILARITY: Belongs to the protein kinase superfamily. ADCK protein kinase family.
SIMILARITY: Contains 1 protein kinase domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -18.1053-0.342 Picture PostScript Text
3' UTR -170.60527-0.324 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR004147 - UbiB_dom

Pfam Domains:
PF03109 - ABC1 family

SCOP Domains:
51445 - (Trans)glycosidases
53756 - UDP-Glycosyltransferase/glycogen phosphorylase
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q9D0L4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003674 molecular_function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0006468 protein phosphorylation
GO:0008150 biological_process
GO:0016310 phosphorylation

Cellular Component:
GO:0005576 extracellular region
GO:0005739 mitochondrion


-  Descriptions from all associated GenBank mRNAs
  AK011310 - Mus musculus 10 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2610005A10 product:aarF domain containing kinase 1, full insert sequence.
AK154839 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630108N21 product:aarF domain containing kinase 1, full insert sequence.
AK050868 - Mus musculus 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030027K04 product:aarF domain containing kinase 1, full insert sequence.
AK044573 - Mus musculus adult retina cDNA, RIKEN full-length enriched library, clone:A930024D12 product:unclassifiable, full insert sequence.
BC010539 - Mus musculus aarF domain containing kinase 1, mRNA (cDNA clone MGC:19303 IMAGE:4162365), complete cds.
AK186264 - Mus musculus cDNA, clone:Y0G0136M12, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000021434, based on BLAT search.
AK186455 - Mus musculus cDNA, clone:Y0G0137G07, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000021434, based on BLAT search.
AK210091 - Mus musculus cDNA, clone:Y2G0117E22, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000021434, based on BLAT search.
AK180214 - Mus musculus cDNA, clone:Y0G0113F06, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000021434, based on BLAT search.
AK145987 - Mus musculus 14 days pregnant adult female placenta cDNA, RIKEN full-length enriched library, clone:I530022J17 product:aarF domain containing kinase 1, full insert sequence.
AK218268 - Mus musculus cDNA, clone:Y2G0144J12, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000021434, based on BLAT search.

-  Other Names for This Gene
  Alternate Gene Symbols: ADCK1_MOUSE, NM_001277297, Q3UKJ2, Q9D0L4, uc007oju.1, uc007oju.2, uc007oju.3
UCSC ID: uc007oju.3
RefSeq Accession: NM_001277297
Protein: Q9D0L4 (aka ADCK1_MOUSE)
CCDS: CCDS26087.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.