ID:FOXN3_MOUSE DESCRIPTION: RecName: Full=Forkhead box protein N3; AltName: Full=Checkpoint suppressor 1; FUNCTION: Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints) (By similarity). SUBUNIT: Interacts through its C-terminus with the C-terminus of SNW1/SKIP (By similarity). SUBCELLULAR LOCATION: Nucleus (Probable). SIMILARITY: Contains 1 fork-head DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q499D0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0008022 protein C-terminus binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0007049 cell cycle GO:0007095 mitotic G2 DNA damage checkpoint GO:0030154 cell differentiation GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0097094 craniofacial suture morphogenesis
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