Mouse Gene Serpinb9 (ENSMUST00000006391.4) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus serine (or cysteine) peptidase inhibitor, clade B, member 9 (Serpinb9), mRNA. (from RefSeq NM_009256)
Gencode Transcript: ENSMUST00000006391.4
Gencode Gene: ENSMUSG00000045827.10
Transcript (Including UTRs)
   Position: mm10 chr13:33,004,541-33,017,955 Size: 13,415 Total Exon Count: 7 Strand: +
Coding Region
   Position: mm10 chr13:33,006,543-33,015,848 Size: 9,306 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:33,004,541-33,017,955)mRNA (may differ from genome)Protein (374 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: O08797_MOUSE
DESCRIPTION: SubName: Full=Protein Serpinb9; SubName: Full=SPI6; SubName: Full=Serine (Or cysteine) peptidase inhibitor, clade B, member 9;
SIMILARITY: Belongs to the serpin family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -48.90165-0.296 Picture PostScript Text
3' UTR -517.402107-0.246 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023795 - Protease_inhib_I4_serpin_CS
IPR000240 - Serpin_B9/Maspin
IPR023796 - Serpin_dom
IPR000215 - Serpin_fam

Pfam Domains:
PF00079 - Serpin (serine protease inhibitor)

SCOP Domains:
56574 - Serpins

ModBase Predicted Comparative 3D Structure on O08797
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD Ensembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0002020 protease binding
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Biological Process:
GO:0001913 T cell mediated cytotoxicity
GO:0002438 acute inflammatory response to antigenic stimulus
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0009617 response to bacterium
GO:0010628 positive regulation of gene expression
GO:0010951 negative regulation of endopeptidase activity
GO:0033668 negative regulation by symbiont of host apoptotic process
GO:0042270 protection from natural killer cell mediated cytotoxicity
GO:0042742 defense response to bacterium
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0070233 negative regulation of T cell apoptotic process

Cellular Component:
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AK161581 - Mus musculus adult male pituitary gland cDNA, RIKEN full-length enriched library, clone:5330428E02 product:serine (or cysteine) proteinase inhibitor, clade B, member 9, full insert sequence.
AK035624 - Mus musculus adult male urinary bladder cDNA, RIKEN full-length enriched library, clone:9530078B17 product:serine protease inhibitor 6, full insert sequence.
BC029900 - Mus musculus serine (or cysteine) peptidase inhibitor, clade B, member 9, mRNA (cDNA clone MGC:36172 IMAGE:4925100), complete cds.
AK087785 - Mus musculus 2 days pregnant adult female ovary cDNA, RIKEN full-length enriched library, clone:E330020F02 product:serine protease inhibitor 6, full insert sequence.
U96700 - Mus musculus SPI6 (Serpinb9) mRNA, complete cds.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu05146 - Amoebiasis

-  Other Names for This Gene
  Alternate Gene Symbols: mCG_17886, NM_009256, O08797, O08797_MOUSE, uc007pzz.1
UCSC ID: uc007pzz.1
RefSeq Accession: NM_009256
Protein: O08797 CCDS: CCDS26431.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.