ID:CTSR3_MOUSE DESCRIPTION: RecName: Full=Cation channel sperm-associated protein 3; Short=CatSper3; FUNCTION: Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization. Contrary to the human ortholog, not activated by progesterone. SUBUNIT: Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of the CatSper complex. Interacts with CATSPER1. SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail. TISSUE SPECIFICITY: Testis-specific. DEVELOPMENTAL STAGE: Detected in hte testis during postnatal development at day 15. Restricted to the late-stage germline cells that line the seminiferous tubules. DISRUPTION PHENOTYPE: Mice are normal but males are sterile. Male sterility is due to defects in sperm motility unability to fertilize intact eggs. SIMILARITY: Belongs to the cation channel sperm-associated (TC 1.A.1.19) family. SEQUENCE CAUTION: Sequence=AAH89518.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q80W99
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
