ID:TOP2B_MOUSE DESCRIPTION: RecName: Full=DNA topoisomerase 2-beta; EC=5.99.1.3; AltName: Full=DNA topoisomerase II, beta isozyme; FUNCTION: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene (By similarity). CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining of double-stranded DNA. SUBUNIT: Homodimer. Component of the WINAC complex, at least composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B (By similarity). INTERACTION: Q9WVE0:Aicda; NbExp=3; IntAct=EBI-2325586, EBI-3835567; SUBCELLULAR LOCATION: Nucleus, nucleolus. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). MISCELLANEOUS: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils. SIMILARITY: Belongs to the type II topoisomerase family. SIMILARITY: Contains 1 Toprim domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00204 - DNA gyrase B PF00521 - DNA gyrase/topoisomerase IV, subunit A PF01751 - Toprim domain PF02518 - Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PF08070 - DTHCT (NUC029) region PF16898 - C-terminal associated domain of TOPRIM
SCOP Domains: 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 54211 - Ribosomal protein S5 domain 2-like 56719 - Type II DNA topoisomerase
ModBase Predicted Comparative 3D Structure on Q64511
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000712 resolution of meiotic recombination intermediates GO:0000819 sister chromatid segregation GO:0001764 neuron migration GO:0006259 DNA metabolic process GO:0006265 DNA topological change GO:0007409 axonogenesis GO:0007569 cell aging GO:0030900 forebrain development GO:0044774 mitotic DNA integrity checkpoint GO:0070301 cellular response to hydrogen peroxide GO:0071318 cellular response to ATP GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining
BioCarta from NCI Cancer Genome Anatomy Project m_DNAfragmentPathway - Apoptotic DNA fragmentation and tissue homeostasis m_vdrPathway - Control of Gene Expression by Vitamin D Receptor
Reactome (by CSHL, EBI, and GO)
Protein Q64511 (Reactome details) participates in the following event(s):