ID:ADK_MOUSE DESCRIPTION: RecName: Full=Adenosine kinase; Short=AK; EC=2.7.1.20; AltName: Full=Adenosine 5'-phosphotransferase; FUNCTION: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides. CATALYTIC ACTIVITY: ATP + adenosine = ADP + AMP. COFACTOR: Binds 3 magnesium ions per subunit (By similarity). ENZYME REGULATION: Activity is inhibited by 5-iodotubercidin and 5'-amino-5'-deoxyadenosine (By similarity). PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1. SUBUNIT: Monomer (By similarity). TISSUE SPECIFICITY: Highest expression in liver, testis, kidney and spleen. Lower expression in brain. Isoform Long is predominant in testis and kidney and isoform Short is predominant in the spleen. SIMILARITY: Belongs to the carbohydrate kinase PfkB family. SEQUENCE CAUTION: Sequence=AAA91649.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P55264
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.