ID:SFTPD_MOUSE DESCRIPTION: RecName: Full=Pulmonary surfactant-associated protein D; Short=PSP-D; Short=SP-D; AltName: Full=Lung surfactant protein D; Flags: Precursor; FUNCTION: Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. SUBUNIT: Oligomeric complex of 4 set of homotrimers. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film. MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C). SIMILARITY: Belongs to the SFTPD family. SIMILARITY: Contains 1 C-type lectin domain. SIMILARITY: Contains 1 collagen-like domain. WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=Pulmonary surfactant protein SP-D; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_170";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P50404
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002376 immune system process GO:0007585 respiratory gaseous exchange GO:0008228 opsonization GO:0032703 negative regulation of interleukin-2 production GO:0042130 negative regulation of T cell proliferation GO:0043129 surfactant homeostasis GO:0043152 induction of bacterial agglutination GO:0045087 innate immune response GO:0048286 lung alveolus development GO:0050765 negative regulation of phagocytosis GO:0050766 positive regulation of phagocytosis GO:0050828 regulation of liquid surface tension GO:0052405 negative regulation by host of symbiont molecular function GO:1905226 regulation of adhesion of symbiont to host epithelial cell
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