Mouse Gene Gzmc (ENSMUST00000015585.3) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus granzyme C (Gzmc), mRNA. (from RefSeq NM_010371)
RefSeq Summary (NM_010371): This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate a mature protein product. This product, expressed by activated T cells, may induce apoptosis of target cells. This gene is present in a gene cluster with other members of the granzyme subfamily on chromosome 14. [provided by RefSeq, Sep 2015].
Gencode Transcript: ENSMUST00000015585.3
Gencode Gene: ENSMUSG00000079186.3
Transcript (Including UTRs)
   Position: mm10 chr14:56,231,441-56,234,656 Size: 3,216 Total Exon Count: 5 Strand: -
Coding Region
   Position: mm10 chr14:56,231,514-56,234,582 Size: 3,069 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:56,231,441-56,234,656)mRNA (may differ from genome)Protein (248 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsMGIPubMed
SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: Q0VB76_MOUSE
DESCRIPTION: SubName: Full=Granzyme C; SubName: Full=MCG130824, isoform CRA_a;
SIMILARITY: Belongs to the peptidase S1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -13.6074-0.184 Picture PostScript Text
3' UTR -17.1073-0.234 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009003 - Pept_cys/ser_Trypsin-like
IPR018114 - Peptidase_S1/S6_AS
IPR001254 - Peptidase_S1_S6
IPR001314 - Peptidase_S1A

Pfam Domains:
PF00089 - Trypsin
PF13365 - Trypsin-like peptidase domain

SCOP Domains:
50494 - Trypsin-like serine proteases

ModBase Predicted Comparative 3D Structure on Q0VB76
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBank     
Protein Sequence     
Alignment     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004252 serine-type endopeptidase activity

Biological Process:
GO:0006508 proteolysis


-  Descriptions from all associated GenBank mRNAs
  X14094 - Mouse mRNA for MCSP-3 mouse CTL serine protease 3.
M36902 - Mouse serine protease mRNA, complete cds.
M12301 - Mouse B10 mRNA encoding T-cell specific protein CCPII.
X12822 - Mouse B10 mRNA for cytotoxic cell protease 2 (CCP2).
M18459 - Mouse granzyme C serine esterase mRNA, complete cds.
BC120755 - Mus musculus granzyme C, mRNA (cDNA clone MGC:155992 IMAGE:40129678), complete cds.
BC120757 - Mus musculus granzyme C, mRNA (cDNA clone MGC:155994 IMAGE:40129680), complete cds.
BC145030 - Mus musculus granzyme C, mRNA (cDNA clone MGC:178586 IMAGE:9053578), complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: mCG_130824, NM_010371, Q0VB76, Q0VB76_MOUSE, uc007ubu.1, uc007ubu.2, uc007ubu.3, uc007ubu.4, uc007ubu.5
UCSC ID: uc007ubu.5
RefSeq Accession: NM_010371
Protein: Q0VB76 CCDS: CCDS27146.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.