Mouse Gene Kcnrg (ENSMUST00000051184.9) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus potassium channel regulator (Kcnrg), transcript variant 1, mRNA. (from RefSeq NM_001039105)
Gencode Transcript: ENSMUST00000051184.9
Gencode Gene: ENSMUSG00000046168.9
Transcript (Including UTRs)
   Position: mm10 chr14:61,607,482-61,612,826 Size: 5,345 Total Exon Count: 2 Strand: +
Coding Region
   Position: mm10 chr14:61,607,513-61,611,886 Size: 4,374 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:61,607,482-61,612,826)mRNA (may differ from genome)Protein (264 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: KCNRG_MOUSE
DESCRIPTION: RecName: Full=Potassium channel regulatory protein; Short=Potassium channel regulator; AltName: Full=Protein CLLD4;
FUNCTION: Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes (By similarity).
SUBCELLULAR LOCATION: Endoplasmic reticulum (By similarity).
SIMILARITY: Contains 1 BTB (POZ) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.9031-0.255 Picture PostScript Text
3' UTR -247.00940-0.263 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR003131 - T1-type_BTB

Pfam Domains:
PF02214 - BTB/POZ domain

SCOP Domains:
54695 - POZ domain

ModBase Predicted Comparative 3D Structure on Q2TUM3
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0042802 identical protein binding

Biological Process:
GO:0051260 protein homooligomerization
GO:1902260 negative regulation of delayed rectifier potassium channel activity

Cellular Component:
GO:0005783 endoplasmic reticulum


-  Descriptions from all associated GenBank mRNAs
  LF205015 - JP 2014500723-A/12518: Polycomb-Associated Non-Coding RNAs.
LF200009 - JP 2014500723-A/7512: Polycomb-Associated Non-Coding RNAs.
AK053138 - Mus musculus 0 day neonate lung cDNA, RIKEN full-length enriched library, clone:E030012H22 product:hypothetical BTB/POZ domain/K+ channel tetramerisation domain containing protein, full insert sequence.
AY491736 - Mus musculus CLLD4-like protein 29 kDa isoform mRNA, complete cds, alternatively spliced.
AY491737 - Mus musculus CLLD4-like protein 22 kDa isoform mRNA, complete cds, alternatively spliced.
BC147091 - Mus musculus potassium channel regulator, mRNA (cDNA clone MGC:182246 IMAGE:9056140), complete cds.
BC147092 - Mus musculus potassium channel regulator, mRNA (cDNA clone MGC:182235 IMAGE:9056129), complete cds.
BC171997 - Mus musculus potassium channel regulator, mRNA (cDNA clone MGC:198702 IMAGE:9054283), complete cds.
LF241312 - JP 2014500723-A/48815: Polycomb-Associated Non-Coding RNAs.
BC061223 - Mus musculus potassium channel regulator, mRNA (cDNA clone IMAGE:30297072), with apparent retained intron.
MA440592 - JP 2018138019-A/12518: Polycomb-Associated Non-Coding RNAs.
MA435586 - JP 2018138019-A/7512: Polycomb-Associated Non-Coding RNAs.
MA476889 - JP 2018138019-A/48815: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RV87, B7ZWD9, Clld4, KCNRG_MOUSE, NM_001039105, Q2TUM3, Q6P8J6, Q8C6V1, uc007uge.1, uc007uge.2, uc007uge.3
UCSC ID: uc007uge.3
RefSeq Accession: NM_001039105
Protein: Q2TUM3 (aka KCNRG_MOUSE)
CCDS: CCDS27187.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.