Mouse Gene Dpysl2 (ENSMUST00000022629.8) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus dihydropyrimidinase-like 2 (Dpysl2), mRNA. (from RefSeq NM_009955)
Gencode Transcript: ENSMUST00000022629.8
Gencode Gene: ENSMUSG00000022048.8
Transcript (Including UTRs)
   Position: mm10 chr14:66,802,864-66,868,688 Size: 65,825 Total Exon Count: 14 Strand: -
Coding Region
   Position: mm10 chr14:66,805,345-66,868,368 Size: 63,024 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:66,802,864-66,868,688)mRNA (may differ from genome)Protein (572 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: DPYL2_MOUSE
DESCRIPTION: RecName: Full=Dihydropyrimidinase-related protein 2; Short=DRP-2; AltName: Full=Unc-33-like phosphoprotein 2; Short=ULIP-2;
FUNCTION: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton.
SUBUNIT: Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C- terminus of CYFIP1/SRA1 (By similarity). Interacts with HTR4. Interacts with CLN6 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
PTM: Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration.
SIMILARITY: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
CAUTION: Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -77.30320-0.242 Picture PostScript Text
3' UTR -700.002481-0.282 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006680 - Amidohydro_1
IPR011778 - Hydantoinase/dihydroPyrase
IPR011059 - Metal-dep_hydrolase_composite

Pfam Domains:
PF01979 - Amidohydrolase family

SCOP Domains:
51338 - Composite domain of metallo-dependent hydrolases
51556 - Metallo-dependent hydrolases

ModBase Predicted Comparative 3D Structure on O08553
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
 RGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0019901 protein kinase binding
GO:0042802 identical protein binding

Biological Process:
GO:0001975 response to amphetamine
GO:0006897 endocytosis
GO:0007010 cytoskeleton organization
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0007420 brain development
GO:0010975 regulation of neuron projection development
GO:0014049 positive regulation of glutamate secretion
GO:0021510 spinal cord development
GO:0021772 olfactory bulb development
GO:0030154 cell differentiation
GO:0030516 regulation of axon extension
GO:0042220 response to cocaine
GO:0042493 response to drug
GO:0045664 regulation of neuron differentiation
GO:0048489 synaptic vesicle transport

Cellular Component:
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0032991 macromolecular complex
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0043209 myelin sheath
GO:0005874 microtubule


-  Descriptions from all associated GenBank mRNAs
  LF200038 - JP 2014500723-A/7541: Polycomb-Associated Non-Coding RNAs.
BC062955 - Mus musculus dihydropyrimidinase-like 2, mRNA (cDNA clone MGC:86013 IMAGE:30535984), complete cds.
Y10339 - M.musculus mRNA for Ulip2 protein.
X87242 - M.musculus mRNA for unc-33 protein.
MA435615 - JP 2018138019-A/7541: Polycomb-Associated Non-Coding RNAs.
AK084113 - Mus musculus 12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130095L01 product:unclassifiable, full insert sequence.
LF241621 - JP 2014500723-A/49124: Polycomb-Associated Non-Coding RNAs.
LF241622 - JP 2014500723-A/49125: Polycomb-Associated Non-Coding RNAs.
LF241623 - JP 2014500723-A/49126: Polycomb-Associated Non-Coding RNAs.
LF241624 - JP 2014500723-A/49127: Polycomb-Associated Non-Coding RNAs.
LF241632 - JP 2014500723-A/49135: Polycomb-Associated Non-Coding RNAs.
LF241633 - JP 2014500723-A/49136: Polycomb-Associated Non-Coding RNAs.
LF241634 - JP 2014500723-A/49137: Polycomb-Associated Non-Coding RNAs.
LF241641 - JP 2014500723-A/49144: Polycomb-Associated Non-Coding RNAs.
LF241644 - JP 2014500723-A/49147: Polycomb-Associated Non-Coding RNAs.
LF241645 - JP 2014500723-A/49148: Polycomb-Associated Non-Coding RNAs.
LF241647 - JP 2014500723-A/49150: Polycomb-Associated Non-Coding RNAs.
LF241657 - JP 2014500723-A/49160: Polycomb-Associated Non-Coding RNAs.
LF241658 - JP 2014500723-A/49161: Polycomb-Associated Non-Coding RNAs.
MA477198 - JP 2018138019-A/49124: Polycomb-Associated Non-Coding RNAs.
MA477199 - JP 2018138019-A/49125: Polycomb-Associated Non-Coding RNAs.
MA477200 - JP 2018138019-A/49126: Polycomb-Associated Non-Coding RNAs.
MA477201 - JP 2018138019-A/49127: Polycomb-Associated Non-Coding RNAs.
MA477209 - JP 2018138019-A/49135: Polycomb-Associated Non-Coding RNAs.
MA477210 - JP 2018138019-A/49136: Polycomb-Associated Non-Coding RNAs.
MA477211 - JP 2018138019-A/49137: Polycomb-Associated Non-Coding RNAs.
MA477218 - JP 2018138019-A/49144: Polycomb-Associated Non-Coding RNAs.
MA477221 - JP 2018138019-A/49147: Polycomb-Associated Non-Coding RNAs.
MA477222 - JP 2018138019-A/49148: Polycomb-Associated Non-Coding RNAs.
MA477224 - JP 2018138019-A/49150: Polycomb-Associated Non-Coding RNAs.
MA477234 - JP 2018138019-A/49160: Polycomb-Associated Non-Coding RNAs.
MA477235 - JP 2018138019-A/49161: Polycomb-Associated Non-Coding RNAs.
LF241679 - JP 2014500723-A/49182: Polycomb-Associated Non-Coding RNAs.
MA477256 - JP 2018138019-A/49182: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04360 - Axon guidance

Reactome (by CSHL, EBI, and GO)

Protein O08553 (Reactome details) participates in the following event(s):

R-MMU-443783 Interaction of NUMB with L1
R-MMU-399944 Phosphorylation of CRMPs by Cdk5
R-MMU-399947 Tyrosine phosphorylation of CRMPs by Fes
R-MMU-399951 Phosphorylation of CRMPs by GSK3beta
R-MMU-437239 Recycling pathway of L1
R-MMU-373760 L1CAM interactions
R-MMU-399956 CRMPs in Sema3A signaling
R-MMU-422475 Axon guidance
R-MMU-373755 Semaphorin interactions
R-MMU-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: Crmp2, DPYL2_MOUSE, NM_009955, O08553, Q6P5D0, uc007uko.1, uc007uko.2, Ulip2
UCSC ID: uc007uko.2
RefSeq Accession: NM_009955
Protein: O08553 (aka DPYL2_MOUSE)
CCDS: CCDS27224.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.