Mouse Gene Dpysl2 (ENSMUST00000022629.8) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus dihydropyrimidinase-like 2 (Dpysl2), mRNA. (from RefSeq NM_009955)
Gencode Transcript: ENSMUST00000022629.8
Gencode Gene: ENSMUSG00000022048.8
Transcript (Including UTRs)
   Position: mm10 chr14:66,802,864-66,868,688 Size: 65,825 Total Exon Count: 14 Strand: -
Coding Region
   Position: mm10 chr14:66,805,345-66,868,368 Size: 63,024 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr14:66,802,864-66,868,688)mRNA (may differ from genome)Protein (572 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Dihydropyrimidinase-related protein 2; Short=DRP-2; AltName: Full=Unc-33-like phosphoprotein 2; Short=ULIP-2;
FUNCTION: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton.
SUBUNIT: Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C- terminus of CYFIP1/SRA1 (By similarity). Interacts with HTR4. Interacts with CLN6 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
PTM: Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration.
SIMILARITY: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
CAUTION: Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -77.30320-0.242 Picture PostScript Text
3' UTR -700.002481-0.282 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006680 - Amidohydro_1
IPR011778 - Hydantoinase/dihydroPyrase
IPR011059 - Metal-dep_hydrolase_composite

Pfam Domains:
PF01979 - Amidohydrolase family

SCOP Domains:
51338 - Composite domain of metallo-dependent hydrolases
51556 - Metallo-dependent hydrolases

ModBase Predicted Comparative 3D Structure on O08553
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0019901 protein kinase binding
GO:0042802 identical protein binding

Biological Process:
GO:0001975 response to amphetamine
GO:0006897 endocytosis
GO:0007010 cytoskeleton organization
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0007420 brain development
GO:0010975 regulation of neuron projection development
GO:0014049 positive regulation of glutamate secretion
GO:0021510 spinal cord development
GO:0021772 olfactory bulb development
GO:0030154 cell differentiation
GO:0030516 regulation of axon extension
GO:0042220 response to cocaine
GO:0042493 response to drug
GO:0045664 regulation of neuron differentiation
GO:0048489 synaptic vesicle transport

Cellular Component:
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0032991 macromolecular complex
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0043209 myelin sheath
GO:0005874 microtubule

-  Descriptions from all associated GenBank mRNAs
  LF200038 - JP 2014500723-A/7541: Polycomb-Associated Non-Coding RNAs.
BC062955 - Mus musculus dihydropyrimidinase-like 2, mRNA (cDNA clone MGC:86013 IMAGE:30535984), complete cds.
Y10339 - M.musculus mRNA for Ulip2 protein.
X87242 - M.musculus mRNA for unc-33 protein.
MA435615 - JP 2018138019-A/7541: Polycomb-Associated Non-Coding RNAs.
AK084113 - Mus musculus 12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130095L01 product:unclassifiable, full insert sequence.
LF241621 - JP 2014500723-A/49124: Polycomb-Associated Non-Coding RNAs.
LF241622 - JP 2014500723-A/49125: Polycomb-Associated Non-Coding RNAs.
LF241623 - JP 2014500723-A/49126: Polycomb-Associated Non-Coding RNAs.
LF241624 - JP 2014500723-A/49127: Polycomb-Associated Non-Coding RNAs.
LF241632 - JP 2014500723-A/49135: Polycomb-Associated Non-Coding RNAs.
LF241633 - JP 2014500723-A/49136: Polycomb-Associated Non-Coding RNAs.
LF241634 - JP 2014500723-A/49137: Polycomb-Associated Non-Coding RNAs.
LF241641 - JP 2014500723-A/49144: Polycomb-Associated Non-Coding RNAs.
LF241644 - JP 2014500723-A/49147: Polycomb-Associated Non-Coding RNAs.
LF241645 - JP 2014500723-A/49148: Polycomb-Associated Non-Coding RNAs.
LF241647 - JP 2014500723-A/49150: Polycomb-Associated Non-Coding RNAs.
LF241657 - JP 2014500723-A/49160: Polycomb-Associated Non-Coding RNAs.
LF241658 - JP 2014500723-A/49161: Polycomb-Associated Non-Coding RNAs.
MA477198 - JP 2018138019-A/49124: Polycomb-Associated Non-Coding RNAs.
MA477199 - JP 2018138019-A/49125: Polycomb-Associated Non-Coding RNAs.
MA477200 - JP 2018138019-A/49126: Polycomb-Associated Non-Coding RNAs.
MA477201 - JP 2018138019-A/49127: Polycomb-Associated Non-Coding RNAs.
MA477209 - JP 2018138019-A/49135: Polycomb-Associated Non-Coding RNAs.
MA477210 - JP 2018138019-A/49136: Polycomb-Associated Non-Coding RNAs.
MA477211 - JP 2018138019-A/49137: Polycomb-Associated Non-Coding RNAs.
MA477218 - JP 2018138019-A/49144: Polycomb-Associated Non-Coding RNAs.
MA477221 - JP 2018138019-A/49147: Polycomb-Associated Non-Coding RNAs.
MA477222 - JP 2018138019-A/49148: Polycomb-Associated Non-Coding RNAs.
MA477224 - JP 2018138019-A/49150: Polycomb-Associated Non-Coding RNAs.
MA477234 - JP 2018138019-A/49160: Polycomb-Associated Non-Coding RNAs.
MA477235 - JP 2018138019-A/49161: Polycomb-Associated Non-Coding RNAs.
LF241679 - JP 2014500723-A/49182: Polycomb-Associated Non-Coding RNAs.
MA477256 - JP 2018138019-A/49182: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04360 - Axon guidance

Reactome (by CSHL, EBI, and GO)

Protein O08553 (Reactome details) participates in the following event(s):

R-MMU-443783 Interaction of NUMB with L1
R-MMU-399944 Phosphorylation of CRMPs by Cdk5
R-MMU-399947 Tyrosine phosphorylation of CRMPs by Fes
R-MMU-399951 Phosphorylation of CRMPs by GSK3beta
R-MMU-437239 Recycling pathway of L1
R-MMU-373760 L1CAM interactions
R-MMU-399956 CRMPs in Sema3A signaling
R-MMU-422475 Axon guidance
R-MMU-373755 Semaphorin interactions
R-MMU-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: Crmp2, DPYL2_MOUSE, NM_009955, O08553, Q6P5D0, uc007uko.1, uc007uko.2, Ulip2
UCSC ID: uc007uko.2
RefSeq Accession: NM_009955
Protein: O08553 (aka DPYL2_MOUSE)
CCDS: CCDS27224.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.