Mouse Gene Loxl2 (ENSMUST00000022660.13) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E- cadherin, probably by mediating deamination of histone H3 (By similarity). Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation. (from UniProt P58022) Gencode Transcript: ENSMUST00000022660.13 Gencode Gene: ENSMUSG00000034205.16 Transcript (Including UTRs) Position: mm10 chr14:69,609,068-69,695,834 Size: 86,767 Total Exon Count: 14 Strand: + Coding Region Position: mm10 chr14:69,633,927-69,693,119 Size: 59,193 Coding Exon Count: 13
ID:LOXL2_MOUSE DESCRIPTION: RecName: Full=Lysyl oxidase homolog 2; EC=1.4.3.13; AltName: Full=Lysyl oxidase-like protein 2; Flags: Precursor; FUNCTION: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E- cadherin, probably by mediating deamination of histone H3 (By similarity). Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation. CATALYTIC ACTIVITY: Peptidyl-L-lysyl-peptide + O(2) + H(2)O = peptidyl-allysyl-peptide + NH(3) + H(2)O(2). COFACTOR: Copper (By similarity). COFACTOR: Contains 1 lysine tyrosylquinone (By similarity). ENZYME REGULATION: Specifically inhibited by a mouse monoclonal antibody AB0023, inhibition occurs in a non-competitive manner (By similarity). SUBUNIT: Component of some chromatin repressor complex. Interacts with SNAI1 (By similarity). SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane (By similarity). Nucleus (By similarity). Chromosome (By similarity). Note=Associated with chromatin (By similarity). It is unclear how LOXL2 is nuclear: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, different reports confirmed the intracellular location and its key role in transcription regulation. TISSUE SPECIFICITY: Ubiquitous. Highest expression in skin, lung and thymus. Present in chondrocytes: mainly expressed by chondrocytes in healing fractures and in epiphyseal growth plates (at protein level). INDUCTION: Strongly induced in hypoxia. PTM: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine (By similarity). SIMILARITY: Belongs to the lysyl oxidase family. SIMILARITY: Contains 4 SRCR domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P58022
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004720 protein-lysine 6-oxidase activity GO:0005044 scavenger receptor activity GO:0005507 copper ion binding GO:0016491 oxidoreductase activity GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0046872 metal ion binding GO:0070492 oligosaccharide binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001666 response to hypoxia GO:0001837 epithelial to mesenchymal transition GO:0001935 endothelial cell proliferation GO:0002040 sprouting angiogenesis GO:0006325 chromatin organization GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006464 cellular protein modification process GO:0006898 receptor-mediated endocytosis GO:0010718 positive regulation of epithelial to mesenchymal transition GO:0018057 peptidyl-lysine oxidation GO:0030199 collagen fibril organization GO:0032332 positive regulation of chondrocyte differentiation GO:0043542 endothelial cell migration GO:0045892 negative regulation of transcription, DNA-templated GO:0046688 response to copper ion GO:0055114 oxidation-reduction process GO:0070828 heterochromatin organization GO:1902455 negative regulation of stem cell population maintenance