Mouse Gene Tpt1 (ENSMUST00000110894.8) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus tumor protein, translationally-controlled 1 (Tpt1), mRNA. (from RefSeq NM_009429)
Gencode Transcript: ENSMUST00000110894.8
Gencode Gene: ENSMUSG00000060126.14
Transcript (Including UTRs)
   Position: mm10 chr14:75,845,093-75,848,415 Size: 3,323 Total Exon Count: 6 Strand: +
Coding Region
   Position: mm10 chr14:75,845,429-75,848,101 Size: 2,673 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:75,845,093-75,848,415)mRNA (may differ from genome)Protein (172 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: TCTP_MOUSE
DESCRIPTION: RecName: Full=Translationally-controlled tumor protein; Short=TCTP; AltName: Full=21 kDa polypeptide; AltName: Full=p21; AltName: Full=p23;
FUNCTION: Involved in calcium binding and microtubule stabilization (By similarity).
SUBUNIT: Seems to self-interact. Interacts with STEAP3 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
DEVELOPMENTAL STAGE: Preferentially synthesized in cells of the early growth phase of Ehrlich ascites tumor.
SIMILARITY: Belongs to the TCTP family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -142.90336-0.425 Picture PostScript Text
3' UTR -68.80314-0.219 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011057 - Mss4-like
IPR011323 - Mss4/transl-control_tumor
IPR018103 - Translation_control_tumour_CS
IPR018105 - Translational_control_tumour_p

Pfam Domains:
PF00838 - Translationally controlled tumour protein

SCOP Domains:
51316 - Mss4-like

ModBase Predicted Comparative 3D Structure on P63028
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details    Gene Details
Gene Sorter    Gene Sorter
 RGDEnsemblEnsemblWormBaseSGD
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0008134 transcription factor binding

Biological Process:
GO:0007283 spermatogenesis
GO:0019827 stem cell population maintenance
GO:0030154 cell differentiation
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000384 negative regulation of ectoderm development

Cellular Component:
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005771 multivesicular body
GO:0005829 cytosol
GO:0045298 tubulin complex


-  Descriptions from all associated GenBank mRNAs
  AK166584 - Mus musculus 5 days embryo whole body cDNA, RIKEN full-length enriched library, clone:I0C0031O13 product:tumor protein, translationally-controlled 1, full insert sequence.
AK169730 - Mus musculus 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430014B07 product:tumor protein, translationally-controlled 1, full insert sequence.
AK149695 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:G530010M06 product:tumor protein, translationally-controlled 1, full insert sequence.
AK150500 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830008K20 product:tumor protein, translationally-controlled 1, full insert sequence.
AK151266 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830027H06 product:tumor protein, translationally-controlled 1, full insert sequence.
AK151375 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830028L20 product:tumor protein, translationally-controlled 1, full insert sequence.
AK151894 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830042B05 product:tumor protein, translationally-controlled 1, full insert sequence.
AK152690 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830082K24 product:tumor protein, translationally-controlled 1, full insert sequence.
AK159516 - Mus musculus osteoclast-like cell cDNA, RIKEN full-length enriched library, clone:I420022J10 product:tumor protein, translationally-controlled 1, full insert sequence.
AK165736 - Mus musculus 13 days embryo brain cDNA, RIKEN full-length enriched library, clone:G630034J21 product:tumor protein, translationally-controlled 1, full insert sequence.
AK167413 - Mus musculus 13 days pregnant adult female placenta cDNA, RIKEN full-length enriched library, clone:I530012I04 product:tumor protein, translationally-controlled 1, full insert sequence.
AK167936 - Mus musculus TIB-55 BB88 cDNA, RIKEN full-length enriched library, clone:I730042C17 product:tumor protein, translationally-controlled 1, full insert sequence.
AK168151 - Mus musculus CRL-1722 L5178Y-R cDNA, RIKEN full-length enriched library, clone:I730061H02 product:tumor protein, translationally-controlled 1, full insert sequence.
AK150858 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830016F10 product:tumor protein, translationally-controlled 1, full insert sequence.
AK151059 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830022F13 product:tumor protein, translationally-controlled 1, full insert sequence.
AK152808 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830086J22 product:tumor protein, translationally-controlled 1, full insert sequence.
AK159565 - Mus musculus osteoclast-like cell cDNA, RIKEN full-length enriched library, clone:I420023P12 product:tumor protein, translationally-controlled 1, full insert sequence.
X06407 - Mouse mRNA for 21 kd polypeptide under translational control.
AK150300 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830002C15 product:tumor protein, translationally-controlled 1, full insert sequence.
BC092381 - Mus musculus tumor protein, translationally-controlled 1, mRNA (cDNA clone MGC:106689 IMAGE:6824238), complete cds.
AK198991 - Mus musculus cDNA, clone:Y1G0129M20, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000022581, based on BLAT search.
AK204264 - Mus musculus cDNA, clone:Y1G0147M16, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000061080, based on BLAT search.
AK191401 - Mus musculus cDNA, clone:Y1G0105M06, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000061080, based on BLAT search.
AK203479 - Mus musculus cDNA, clone:Y1G0145A16, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000022581, based on BLAT search.
AK199313 - Mus musculus cDNA, clone:Y1G0130M19, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000022581, based on BLAT search.
AK198939 - Mus musculus cDNA, clone:Y1G0129K09, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000022581, based on BLAT search.
AK204488 - Mus musculus cDNA, clone:Y1G0148J17, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000022581, based on BLAT search.
AK075839 - Mus musculus adult male stomach cDNA, RIKEN full-length enriched library, clone:2210402K04 product:inferred: 21 kd polypeptide, full insert sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_009429, P14701, P63028, Q3TMT0, Q3TWS8, Q3TWX0, Q3UAG7, Q569M9, TCTP_MOUSE, Trt, uc007uqz.1, uc007uqz.2, uc007uqz.3
UCSC ID: uc007uqz.3
RefSeq Accession: NM_009429
Protein: P63028 (aka TCTP_MOUSE)
CCDS: CCDS36980.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.