Mouse Gene Lmo7 (uc007uwb.2) Description and Page Index
  Description: SubName: Full=MKIAA0858 protein; Flags: Fragment;
Transcript (Including UTRs)
   Position: mm9 chr14:102,239,865-102,333,910 Size: 94,046 Total Exon Count: 27 Strand: +
Coding Region
   Position: mm9 chr14:102,283,417-102,333,205 Size: 49,789 Coding Exon Count: 23 

Page IndexSequence and LinksUniProtKB CommentsCTDMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2011-03-02

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:102,239,865-102,333,910)mRNA (may differ from genome)Protein (1453 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAllen Brain Atlas
BioGPSCGAPEnsemblExonPrimerGeneCardsGeneNetwork
MGIPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: Q6ZQ32_MOUSE
DESCRIPTION: SubName: Full=MKIAA0858 protein; Flags: Fragment;
SIMILARITY: Contains 1 PDZ (DHR) domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D013749 Tetrachlorodibenzodioxin
  • C023514 2,6-dinitrotoluene
  • D004052 Diethylnitrosamine
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C014211 2,3,7,8-tetrachlorodibenzofuran
  • C016403 2,4-dinitrotoluene
  • C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester
  • C009505 4,4'-diaminodiphenylmethane
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • D016604 Aflatoxin B1
          more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from GNF1M Mouse Chip

    
     
      
       
     
    
   
Ratios
    
     
      
       
     
    
   
Absolute
     
     
     
    
   
     
Ratios
     
     
     
    
   
     
Absolute

Rinn et. al Sex Gene Expression Data on MOE430A Chip

        
Ratios
        
Absolute

GNF Expression Atlas Data from U74a Mouse Chip

        
     
    
    
    
   
    
Ratios
        
     
    
    
    
   
    
Absolute
    
     
    
Ratios
    
     
    
Absolute

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -215.10713-0.302 Picture PostScript Text
3' UTR -155.38705-0.220 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001715 - CH-domain
IPR001478 - PDZ

Pfam Domains:
PF00595 - PDZ domain (Also known as DHR or GLGF)

SCOP Domains:
50156 - PDZ domain-like

ModBase Predicted Comparative 3D Structure on Q6ZQ32
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
GenBankRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004842 ubiquitin-protein transferase activity
GO:0008022 protein C-terminus binding
GO:0042805 actinin binding

Biological Process:
GO:0016567 protein ubiquitination
GO:0023051 regulation of signaling
GO:0030155 regulation of cell adhesion

Cellular Component:
GO:0005913 cell-cell adherens junction
GO:0016324 apical plasma membrane


-  Descriptions from all associated GenBank mRNAs
  EF071857 - Mus musculus LIM domain only 7 (Lmo7) mRNA, complete cds.
BC082553 - Mus musculus LIM domain only 7, mRNA (cDNA clone IMAGE:30617667).
AK053129 - Mus musculus 0 day neonate lung cDNA, RIKEN full-length enriched library, clone:E030010D13 product:inferred: unnamed protein product {Homo sapiens}, full insert sequence.
AK143133 - Mus musculus 0 day neonate eyeball cDNA, RIKEN full-length enriched library, clone:E130113D23 product:LIM domain only 7, full insert sequence.
AK129231 - Mus musculus mRNA for mKIAA0858 protein.
BC049164 - Mus musculus LIM domain only 7, mRNA (cDNA clone IMAGE:6474901), partial cds.
BC145011 - Mus musculus LIM domain only 7, mRNA (cDNA clone MGC:178567 IMAGE:9053559), complete cds.
AK137694 - Mus musculus adult female vagina cDNA, RIKEN full-length enriched library, clone:9930037L20 product:LIM domain only 7, full insert sequence.
AK164481 - Mus musculus 13 days embryo heart cDNA, RIKEN full-length enriched library, clone:D330003O20 product:LIM domain only 7, full insert sequence.
AK047836 - Mus musculus 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130003G01 product:similar to LIM protein [Homo sapiens], full insert sequence.
AK052938 - Mus musculus 16 days neonate heart cDNA, RIKEN full-length enriched library, clone:D830050B15 product:unclassifiable, full insert sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04520 - Adherens junction

-  Other Names for This Gene
  Alternate Gene Symbols: AK129231, mKIAA0858, Q6ZQ32, Q6ZQ32_MOUSE, uc007uwb.1
UCSC ID: uc007uwb.2
RefSeq Accession: NM_201529
Protein: Q6ZQ32

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK129231.1
exon count: 27CDS single in 3' UTR: no RNA size: 5774
ORF size: 4362CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 7949.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 224# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.