Mouse Gene Il7r (ENSMUST00000003981.5) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus interleukin 7 receptor (Il7r), transcript variant 2, mRNA. (from RefSeq NM_008372) RefSeq Summary (NM_008372): Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENSMUST00000003981.5 Gencode Gene: ENSMUSG00000003882.5 Transcript (Including UTRs) Position: mm10 chr15:9,505,788-9,529,835 Size: 24,048 Total Exon Count: 8 Strand: - Coding Region Position: mm10 chr15:9,507,855-9,529,742 Size: 21,888 Coding Exon Count: 8
ID:IL7RA_MOUSE DESCRIPTION: RecName: Full=Interleukin-7 receptor subunit alpha; Short=IL-7 receptor subunit alpha; Short=IL-7R subunit alpha; Short=IL-7R-alpha; Short=IL-7RA; AltName: CD_antigen=CD127; Flags: Precursor; FUNCTION: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). SUBUNIT: The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Spleen, thymus and fetal liver. DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding. DOMAIN: The box 1 motif is required for JAK interaction and/or activation. PTM: N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form (By similarity). SIMILARITY: Belongs to the type I cytokine receptor family. Type 4 subfamily. SIMILARITY: Contains 1 fibronectin type-III domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P16872
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000902 cell morphogenesis GO:0001915 negative regulation of T cell mediated cytotoxicity GO:0002377 immunoglobulin production GO:0008284 positive regulation of cell proliferation GO:0008361 regulation of cell size GO:0010628 positive regulation of gene expression GO:0019221 cytokine-mediated signaling pathway GO:0030217 T cell differentiation GO:0033089 positive regulation of T cell differentiation in thymus GO:0042100 B cell proliferation GO:0048535 lymph node development GO:0048872 homeostasis of number of cells GO:0070233 negative regulation of T cell apoptotic process GO:1904894 positive regulation of STAT cascade
US Server
Sequence and Links to Tools and Databases 
