ID:KCNS2_MOUSE DESCRIPTION: RecName: Full=Potassium voltage-gated channel subfamily S member 2; AltName: Full=Delayed-rectifier K(+) channel alpha subunit 2; AltName: Full=Voltage-gated potassium channel subunit Kv9.2; FUNCTION: Potassium channel subunit. Modulates channel activity and reduces the ion flow. SUBUNIT: Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1. TISSUE SPECIFICITY: Detected in brain, but not in the other tissues tested. Expression was highest in the olfactory bulb, cerebral cortex, hippocampus, habenula, basolateral amygdaloid nuclei and cerebellum. DOMAIN: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. SIMILARITY: Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.2/KCNS2 sub-subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O35174
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005216 ion channel activity GO:0005244 voltage-gated ion channel activity GO:0005249 voltage-gated potassium channel activity GO:0005267 potassium channel activity
Biological Process: GO:0006811 ion transport GO:0006813 potassium ion transport GO:0034765 regulation of ion transmembrane transport GO:0051260 protein homooligomerization GO:0055085 transmembrane transport GO:0071805 potassium ion transmembrane transport GO:1902259 regulation of delayed rectifier potassium channel activity
Cellular Component: GO:0005886 plasma membrane GO:0008076 voltage-gated potassium channel complex GO:0016020 membrane GO:0016021 integral component of membrane GO:0048471 perinuclear region of cytoplasm