Mouse Gene Rims2 (ENSMUST00000227243.1) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus regulating synaptic membrane exocytosis 2 (Rims2), transcript variant 2, mRNA. (from RefSeq NM_001256383)
Gencode Transcript: ENSMUST00000227243.1
Gencode Gene: ENSMUSG00000037386.16
Transcript (Including UTRs)
   Position: mm10 chr15:39,198,338-39,681,846 Size: 483,509 Total Exon Count: 26 Strand: +
Coding Region
   Position: mm10 chr15:39,198,363-39,681,764 Size: 483,402 Coding Exon Count: 26 

Page IndexSequence and LinksPrimersCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:39,198,338-39,681,846)mRNA (may differ from genome)Protein (1550 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKBWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -7.5025-0.300 Picture PostScript Text
3' UTR -11.8082-0.144 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000008 - C2_Ca-dep
IPR008973 - C2_Ca/lipid-bd_dom_CaLB
IPR018029 - C2_membr_targeting
IPR001478 - PDZ
IPR010911 - Rab-bd_domain
IPR017455 - Znf_FYVE-rel
IPR011011 - Znf_FYVE_PHD
IPR013083 - Znf_RING/FYVE/PHD

Pfam Domains:
PF00168 - C2 domain
PF02318 - FYVE-type zinc finger

SCOP Domains:
50156 - PDZ domain-like
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57850 - RING/U-box
57903 - FYVE/PHD zinc finger

ModBase Predicted Comparative 3D Structure on Q0VF51
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0017137 Rab GTPase binding
GO:0046872 metal ion binding

Biological Process:
GO:0006886 intracellular protein transport
GO:0017157 regulation of exocytosis
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter

Cellular Component:
GO:0005622 intracellular
GO:0048786 presynaptic active zone


-  Descriptions from all associated GenBank mRNAs
  AB021131 - Mus musculus RIM2 mRNA, complete cds.
BC118979 - Mus musculus regulating synaptic membrane exocytosis 2, mRNA (cDNA clone MGC:144185 IMAGE:40098740), complete cds.
HM015529 - Mus musculus regulating synaptic membrane exocytosis 2 (Rims2) mRNA, complete cds.
AK129206 - Mus musculus mRNA for mKIAA0751 protein.
AK012864 - Mus musculus 10, 11 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2810036I15 product:Rab3 interacting protein 1, full insert sequence.
AK083172 - Mus musculus adult male hippocampus cDNA, RIKEN full-length enriched library, clone:C630023J21 product:Rab3 interacting protein 1, full insert sequence.
AK202176 - Mus musculus cDNA, clone:Y1G0140J22, strand:unspecified.
AK032619 - Mus musculus adult male olfactory brain cDNA, RIKEN full-length enriched library, clone:6430709C16 product:Rab3 interacting protein 1, full insert sequence.
AK200357 - Mus musculus cDNA, clone:Y1G0134E24, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000042917, based on BLAT search.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001256383, Q0VF51, Q0VF51_MOUSE, uc007voe.1, uc007voe.2, uc007voe.3
UCSC ID: uc007voe.3
RefSeq Accession: NM_001256383
Protein: Q0VF51 CCDS: CCDS37067.1, CCDS56982.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.