ID:MAFA_MOUSE DESCRIPTION: RecName: Full=Transcription factor MafA; AltName: Full=Pancreatic beta-cell-specific transcriptional activator; AltName: Full=V-maf musculoaponeurotic fibrosarcoma oncogene homolog A; FUNCTION: Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity (By similarity). Regulates the insulin gene transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. SUBUNIT: Binds DNA as a homodimer (By similarity). Interacts with PCAF (By similarity). Interacts with NEUROD1 and PDX1. SUBCELLULAR LOCATION: Nucleus. Note=Detected in nuclei of pancreas islet beta cells. TISSUE SPECIFICITY: Selectively expressed in pancreatic beta but not in alpha cells (at protein level). Expressed in eyes and at low levels in thymus. Expressed in brain, lung, spleen and kidney. Expressed in embryo. DEVELOPMENTAL STAGE: Expressed on E14. During fetal period (12.5 dpc) detected in each formed somite and expression appears to be in the myotomal cells. Also expressed in the head neural tube and liver cells. Expressed at low levels some mesenchyme-like cells. PTM: Ubiquitinated, leading to its degradation by the proteasome (By similarity). PTM: Phosphorylation by GSK3 requires prior phosphorylation of Ser-65 by another kinase. Phosphorylation proceeds then from Ser- 61 to Thr-57, Thr-53 and Ser-49. GSK3-mediated phosphorylation increases its transcriptional activity through the recruitment of the coactivator PCAF, is required for its transforming activity and leads to its degradation through an ubiquitin/proteasome- dependent pathway (By similarity). Ser-14 and Ser-65 appear to be the major phosphorylation sites. Phosphorylated by MAPK13 on serine and threonine residues (Probable). DISRUPTION PHENOTYPE: Mice show a normal pancreatic morphology at birth, but after birth a reduction in the proportion of beta-cells with resulting impaired glucose tolerance and diabetes. SIMILARITY: Belongs to the bZIP family. Maf subfamily. SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8CF90
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
