Mouse Gene Bop1 (ENSMUST00000023217.10) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus block of proliferation 1 (Bop1), mRNA. (from RefSeq NM_013481)
Gencode Transcript: ENSMUST00000023217.10
Gencode Gene: ENSMUSG00000022557.11
Transcript (Including UTRs)
   Position: mm10 chr15:76,452,989-76,477,277 Size: 24,289 Total Exon Count: 16 Strand: -
Coding Region
   Position: mm10 chr15:76,453,225-76,477,221 Size: 23,997 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:76,452,989-76,477,277)mRNA (may differ from genome)Protein (732 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
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-  Comments and Description Text from UniProtKB
  ID: BOP1_MOUSE
DESCRIPTION: RecName: Full=Ribosome biogenesis protein BOP1; AltName: Full=Block of proliferation 1 protein;
FUNCTION: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
SUBUNIT: Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
SUBCELLULAR LOCATION: Nucleus, nucleolus. Nucleus, nucleoplasm.
TISSUE SPECIFICITY: Expressed in brain, gut, heart, kidney, liver, lung, muscle, ovary, skin, spleen and testis.
INDUCTION: Expression in quiescent fibroblasts is induced by serum stimulation.
SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
SIMILARITY: Contains 7 WD repeats.
SEQUENCE CAUTION: Sequence=BAC97868.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -23.9056-0.427 Picture PostScript Text
3' UTR -68.80236-0.292 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012953 - BOP1_N_dom
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR019775 - WD40_repeat_CS
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF00400 - WD domain, G-beta repeat
PF08145 - BOP1NT (NUC169) domain

SCOP Domains:
50952 - Soluble quinoprotein glucose dehydrogenase
50956 - Thermostable phytase (3-phytase)
50960 - TolB, C-terminal domain
63825 - YWTD domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
117289 - Nucleoporin domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Peptidase/esterase 'gauge' domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - DPP6 N-terminal domain-like

ModBase Predicted Comparative 3D Structure on P97452
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details    Gene Details
Gene Sorter    Gene Sorter
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Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0043021 ribonucleoprotein complex binding

Biological Process:
GO:0000027 ribosomal large subunit assembly
GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0008283 cell proliferation
GO:0042254 ribosome biogenesis
GO:0042273 ribosomal large subunit biogenesis
GO:0051726 regulation of cell cycle
GO:1901796 regulation of signal transduction by p53 class mediator

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0030687 preribosome, large subunit precursor
GO:0070545 PeBoW complex
GO:1990904 ribonucleoprotein complex


-  Descriptions from all associated GenBank mRNAs
  AK194272 - Mus musculus cDNA, clone:Y1G0114M20, strand:unspecified.
AK190269 - Mus musculus cDNA, clone:Y1G0102E02, strand:unspecified.
AK199218 - Mus musculus cDNA, clone:Y1G0130I10, strand:unspecified.
AK168127 - Mus musculus CRL-1722 L5178Y-R cDNA, RIKEN full-length enriched library, clone:I730059I18 product:block of proliferation 1, full insert sequence.
AK144095 - Mus musculus CRL-1751 WEHI 164 cDNA, RIKEN full-length enriched library, clone:G430004A08 product:block of proliferation 1, full insert sequence.
AK187459 - Mus musculus cDNA, clone:Y0G0141O14, strand:unspecified.
AK191694 - Mus musculus cDNA, clone:Y1G0106K21, strand:unspecified.
BC012693 - Mus musculus block of proliferation 1, mRNA (cDNA clone MGC:13949 IMAGE:4193123), complete cds.
AK129058 - Mus musculus mRNA for mKIAA0124 protein.
U77415 - Mus musculus Bop1 mRNA, complete cds.
AK199109 - Mus musculus cDNA, clone:Y1G0130D04, strand:unspecified.
AK079627 - Mus musculus adult male spinal cord cDNA, RIKEN full-length enriched library, clone:A330083B15 product:block of proliferation 1, full insert sequence.
AK167110 - Mus musculus blastocyst blastocyst cDNA, RIKEN full-length enriched library, clone:I1C0031I02 product:block of proliferation 1, full insert sequence.
AK167878 - Mus musculus CRL-1722 L5178Y-R cDNA, RIKEN full-length enriched library, clone:I730035B22 product:block of proliferation 1, full insert sequence.
AK206049 - Mus musculus cDNA, clone:Y2G0103J19, strand:unspecified.
AK198058 - Mus musculus cDNA, clone:Y1G0127A03, strand:unspecified.
AK149725 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:G530013F14 product:Warning: possibly chimeric clone, full insert sequence.
AK167829 - Mus musculus CRL-1722 L5178Y-R cDNA, RIKEN full-length enriched library, clone:I730031N16 product:block of proliferation 1, full insert sequence.
AK167225 - Mus musculus blastocyst blastocyst cDNA, RIKEN full-length enriched library, clone:I1C0042F07 product:block of proliferation 1, full insert sequence.
AK191936 - Mus musculus cDNA, clone:Y1G0107G06, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK203061 - Mus musculus cDNA, clone:Y1G0143K11, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK199244 - Mus musculus cDNA, clone:Y1G0130J18, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK178909 - Mus musculus cDNA, clone:Y0G0108F19, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK187975 - Mus musculus cDNA, clone:Y0G0143K20, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK184320 - Mus musculus cDNA, clone:Y0G0129H21, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK190367 - Mus musculus cDNA, clone:Y1G0102I15, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK191522 - Mus musculus cDNA, clone:Y1G0106C15, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK177135 - Mus musculus cDNA, clone:Y0G0101L13, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK177611 - Mus musculus cDNA, clone:Y0G0103G12, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK180935 - Mus musculus cDNA, clone:Y0G0116G04, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK185180 - Mus musculus cDNA, clone:Y0G0132N24, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK188306 - Mus musculus cDNA, clone:Y0G0144L18, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK185945 - Mus musculus cDNA, clone:Y0G0135M03, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK194810 - Mus musculus cDNA, clone:Y1G0116I03, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK217116 - Mus musculus cDNA, clone:Y2G0140L07, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK209200 - Mus musculus cDNA, clone:Y2G0114F01, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK213349 - Mus musculus cDNA, clone:Y2G0128B04, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK215153 - Mus musculus cDNA, clone:Y2G0134C10, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK205317 - Mus musculus cDNA, clone:Y2G0101F05, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK183760 - Mus musculus cDNA, clone:Y0G0127B02, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK178937 - Mus musculus cDNA, clone:Y0G0108H04, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK187881 - Mus musculus cDNA, clone:Y0G0143F18, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK199312 - Mus musculus cDNA, clone:Y1G0130M18, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK206410 - Mus musculus cDNA, clone:Y2G0104M05, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK180635 - Mus musculus cDNA, clone:Y0G0115D20, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK181923 - Mus musculus cDNA, clone:Y0G0120B22, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK201242 - Mus musculus cDNA, clone:Y1G0137I24, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000023217, based on BLAT search.
AK012448 - Mus musculus 11 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2700056O10 product:unclassifiable, full insert sequence.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P97452 (Reactome details) participates in the following event(s):

R-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-MMU-8868773 rRNA processing in the nucleus and cytosol
R-MMU-72312 rRNA processing
R-MMU-8953854 Metabolism of RNA

-  Other Names for This Gene
  Alternate Gene Symbols: BOP1_MOUSE, Kiaa0124, NM_013481, P97452, Q3TK87, Q6ZQI9, Q91X31, uc007wkf.1, uc007wkf.2
UCSC ID: uc007wkf.2
RefSeq Accession: NM_013481
Protein: P97452 (aka BOP1_MOUSE)
CCDS: CCDS27570.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.