Mouse Gene Lgals1 (ENSMUST00000089377.5) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus lectin, galactose binding, soluble 1 (Lgals1), mRNA. (from RefSeq NM_008495)
Gencode Transcript: ENSMUST00000089377.5
Gencode Gene: ENSMUSG00000068220.6
Transcript (Including UTRs)
Position: mm10 chr15:78,926,725-78,930,465 Size: 3,741 Total Exon Count: 4 Strand: +
Position: mm10 chr15:78,926,796-78,930,144 Size: 3,349 Coding Exon Count: 4
Data last updated at UCSC: 2019-09-19
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Galectin-1; Short=Gal-1; AltName: Full=14 kDa lectin; AltName: Full=Beta-galactoside-binding lectin L-14-I; AltName: Full=Galaptin; AltName: Full=Lactose-binding lectin 1; AltName: Full=Lectin galactoside-binding soluble 1; AltName: Full=S-Lac lectin 1;
FUNCTION: May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates (By similarity). SUBUNIT: Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Interacts with laminin (By similarity). SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity). SIMILARITY: Contains 1 galectin domain. CAUTION: Was originally (PubMed:3020551) thought to originate from human. SEQUENCE CAUTION: Sequence=AAA37313.1; Type=Frameshift; Positions=Several; Sequence=AK004298; Type=Frameshift; Positions=117;
Comparative Toxicogenomics Database (CTD)
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR008985 - ConA-like_lec_gl_sf
IPR013320 - ConA-like_subgrp
IPR015535 - Galectin_1
IPR001079 - Galectin_CRD
Pfam Domains: PF00337 - Galactoside-binding lectin
SCOP Domains: 88633 - Positive stranded ssRNA viruses
49899 - Concanavalin A-like lectins/glucanases
ModBase Predicted Comparative 3D Structure on P16045
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF200360 - JP 2014500723-A/7863: Polycomb-Associated Non-Coding RNAs. X66532 - M.musculus mRNA for L14 lectin. AK004298 - Mus musculus 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110058J24 product:lectin, galactose binding, soluble 1, full insert sequence. BC002063 - Mus musculus lectin, galactose binding, soluble 1, mRNA (cDNA clone MGC:6129 IMAGE:3494931), complete cds. X51903 - Murine mRNA for lactose-binding lectin L-14. X15986 - Mouse 3' mRNA for beta-galactoside specific lectin (14kDa). X53067 - Mouse mRNA for 14KDa lectin. BC099479 - Mus musculus lectin, galactose binding, soluble 1, mRNA (cDNA clone MGC:117697 IMAGE:30841237), complete cds. M57470 - Murine beta-galactoside binding protein mRNA, complete cds. M33214 - Mouse beta-galactoside-binding lectin (L-14.5) mRNA, 5' end. LF245109 - JP 2014500723-A/52612: Polycomb-Associated Non-Coding RNAs. LF245110 - JP 2014500723-A/52613: Polycomb-Associated Non-Coding RNAs. LF245112 - JP 2014500723-A/52615: Polycomb-Associated Non-Coding RNAs. LF245113 - JP 2014500723-A/52616: Polycomb-Associated Non-Coding RNAs. LF245114 - JP 2014500723-A/52617: Polycomb-Associated Non-Coding RNAs. LF245115 - JP 2014500723-A/52618: Polycomb-Associated Non-Coding RNAs. MA435937 - JP 2018138019-A/7863: Polycomb-Associated Non-Coding RNAs. MA480686 - JP 2018138019-A/52612: Polycomb-Associated Non-Coding RNAs. MA480687 - JP 2018138019-A/52613: Polycomb-Associated Non-Coding RNAs. MA480689 - JP 2018138019-A/52615: Polycomb-Associated Non-Coding RNAs. MA480690 - JP 2018138019-A/52616: Polycomb-Associated Non-Coding RNAs. MA480691 - JP 2018138019-A/52617: Polycomb-Associated Non-Coding RNAs. MA480692 - JP 2018138019-A/52618: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO) Protein P16045 ( Reactome details) participates in the following event(s): R-MMU-8878599 Ssc5d binds ligands
R-MMU-8952289 FAM20C phosphorylates FAM20C substrates
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation
R-MMU-392499 Metabolism of proteins
R-MMU-597592 Post-translational protein modification
Other Names for This Gene
Alternate Gene Symbols: Gbp, LEG1_MOUSE, NM_008495, P05163, P11946, P16045, P17601, Q4FZH4, Q99M27, Q9D0X0, uc007wrv.1 UCSC ID: uc007wrv.1 RefSeq Accession: NM_008495
(aka LEG1_MOUSE) P16045
Gene Model Information
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.