Mouse Gene Lgals1 (ENSMUST00000089377.5) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus lectin, galactose binding, soluble 1 (Lgals1), mRNA. (from RefSeq NM_008495)
Gencode Transcript: ENSMUST00000089377.5
Gencode Gene: ENSMUSG00000068220.6
Transcript (Including UTRs)
   Position: mm10 chr15:78,926,725-78,930,465 Size: 3,741 Total Exon Count: 4 Strand: +
Coding Region
   Position: mm10 chr15:78,926,796-78,930,144 Size: 3,349 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:78,926,725-78,930,465)mRNA (may differ from genome)Protein (135 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsMGIPubMed
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: LEG1_MOUSE
DESCRIPTION: RecName: Full=Galectin-1; Short=Gal-1; AltName: Full=14 kDa lectin; AltName: Full=Beta-galactoside-binding lectin L-14-I; AltName: Full=Galaptin; AltName: Full=Lactose-binding lectin 1; AltName: Full=Lectin galactoside-binding soluble 1; AltName: Full=S-Lac lectin 1;
FUNCTION: May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates (By similarity).
SUBUNIT: Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Interacts with laminin (By similarity).
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).
SIMILARITY: Contains 1 galectin domain.
CAUTION: Was originally (PubMed:3020551) thought to originate from human.
SEQUENCE CAUTION: Sequence=AAA37313.1; Type=Frameshift; Positions=Several; Sequence=AK004298; Type=Frameshift; Positions=117;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.0071-0.282 Picture PostScript Text
3' UTR -106.10321-0.331 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008985 - ConA-like_lec_gl_sf
IPR013320 - ConA-like_subgrp
IPR015535 - Galectin_1
IPR001079 - Galectin_CRD

Pfam Domains:
PF00337 - Galactoside-binding lectin

SCOP Domains:
88633 - Positive stranded ssRNA viruses
49899 - Concanavalin A-like lectins/glucanases

ModBase Predicted Comparative 3D Structure on P16045
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
 RGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0005534 galactose binding
GO:0030246 carbohydrate binding
GO:0030395 lactose binding
GO:0042803 protein homodimerization activity
GO:0043236 laminin binding

Biological Process:
GO:0002317 plasma cell differentiation
GO:0006915 apoptotic process
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0010812 negative regulation of cell-substrate adhesion
GO:0010977 negative regulation of neuron projection development
GO:0031295 T cell costimulation
GO:0034120 positive regulation of erythrocyte aggregation
GO:0035900 response to isolation stress
GO:0042493 response to drug
GO:0045445 myoblast differentiation
GO:0046598 positive regulation of viral entry into host cell
GO:0048678 response to axon injury
GO:0071333 cellular response to glucose stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0045185 maintenance of protein location

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009986 cell surface
GO:0031012 extracellular matrix


-  Descriptions from all associated GenBank mRNAs
  LF200360 - JP 2014500723-A/7863: Polycomb-Associated Non-Coding RNAs.
X66532 - M.musculus mRNA for L14 lectin.
AK004298 - Mus musculus 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110058J24 product:lectin, galactose binding, soluble 1, full insert sequence.
BC002063 - Mus musculus lectin, galactose binding, soluble 1, mRNA (cDNA clone MGC:6129 IMAGE:3494931), complete cds.
X51903 - Murine mRNA for lactose-binding lectin L-14.
X15986 - Mouse 3' mRNA for beta-galactoside specific lectin (14kDa).
X53067 - Mouse mRNA for 14KDa lectin.
BC099479 - Mus musculus lectin, galactose binding, soluble 1, mRNA (cDNA clone MGC:117697 IMAGE:30841237), complete cds.
M57470 - Murine beta-galactoside binding protein mRNA, complete cds.
M33214 - Mouse beta-galactoside-binding lectin (L-14.5) mRNA, 5' end.
LF245109 - JP 2014500723-A/52612: Polycomb-Associated Non-Coding RNAs.
LF245110 - JP 2014500723-A/52613: Polycomb-Associated Non-Coding RNAs.
LF245112 - JP 2014500723-A/52615: Polycomb-Associated Non-Coding RNAs.
LF245113 - JP 2014500723-A/52616: Polycomb-Associated Non-Coding RNAs.
LF245114 - JP 2014500723-A/52617: Polycomb-Associated Non-Coding RNAs.
LF245115 - JP 2014500723-A/52618: Polycomb-Associated Non-Coding RNAs.
MA435937 - JP 2018138019-A/7863: Polycomb-Associated Non-Coding RNAs.
MA480686 - JP 2018138019-A/52612: Polycomb-Associated Non-Coding RNAs.
MA480687 - JP 2018138019-A/52613: Polycomb-Associated Non-Coding RNAs.
MA480689 - JP 2018138019-A/52615: Polycomb-Associated Non-Coding RNAs.
MA480690 - JP 2018138019-A/52616: Polycomb-Associated Non-Coding RNAs.
MA480691 - JP 2018138019-A/52617: Polycomb-Associated Non-Coding RNAs.
MA480692 - JP 2018138019-A/52618: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P16045 (Reactome details) participates in the following event(s):

R-MMU-8878599 Ssc5d binds ligands
R-MMU-8952289 FAM20C phosphorylates FAM20C substrates
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation
R-MMU-392499 Metabolism of proteins
R-MMU-597592 Post-translational protein modification

-  Other Names for This Gene
  Alternate Gene Symbols: Gbp, LEG1_MOUSE, NM_008495, P05163, P11946, P16045, P17601, Q4FZH4, Q99M27, Q9D0X0, uc007wrv.1
UCSC ID: uc007wrv.1
RefSeq Accession: NM_008495
Protein: P16045 (aka LEG1_MOUSE)
CCDS: CCDS27628.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.