Mouse Gene H1f0 (ENSMUST00000180086.2) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus H1 histone family, member 0 (H1f0), mRNA. (from RefSeq NM_008197) RefSeq Summary (NM_008197): Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-independent histone :: PMID: 25645921 ##RefSeq-Attributes-END## Gencode Transcript: ENSMUST00000180086.2 Gencode Gene: ENSMUSG00000096210.2 Transcript (Including UTRs) Position: mm10 chr15:79,028,450-79,030,504 Size: 2,055 Total Exon Count: 1 Strand: + Coding Region Position: mm10 chr15:79,028,722-79,029,306 Size: 585 Coding Exon Count: 1
ID:H10_MOUSE DESCRIPTION: RecName: Full=Histone H1.0; AltName: Full=Histone H1'; AltName: Full=Histone H1(0); AltName: Full=MyD196; FUNCTION: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division. SUBCELLULAR LOCATION: Nucleus. Chromosome. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). SIMILARITY: Belongs to the histone H1/H5 family. SIMILARITY: Contains 1 H15 (linker histone H1/H5 globular) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P10922
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
