Mouse Gene Sept3 (ENSMUST00000116423.2) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus septin 3 (Sept3), transcript variant 3, mRNA. (from RefSeq NM_011889)
Gencode Transcript: ENSMUST00000116423.2
Gencode Gene: ENSMUSG00000022456.18
Transcript (Including UTRs)
   Position: mm10 chr15:82,274,893-82,292,066 Size: 17,174 Total Exon Count: 10 Strand: +
Coding Region
   Position: mm10 chr15:82,279,444-82,290,873 Size: 11,430 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:82,274,893-82,292,066)mRNA (may differ from genome)Protein (337 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: SEPT3_MOUSE
DESCRIPTION: RecName: Full=Neuronal-specific septin-3;
FUNCTION: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).
SUBUNIT: Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity).
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Cell junction, synapse (By similarity).
PTM: Phosphorylated by PKG on serine residues. Phosphorylated by PKG on Ser-91 (By similarity).
SIMILARITY: Belongs to the septin family.
SEQUENCE CAUTION: Sequence=AAD02884.1; Type=Frameshift; Positions=344;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -80.60190-0.424 Picture PostScript Text
3' UTR -392.001193-0.329 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000038 - Cell_div_GTP-bd
IPR016491 - Septin
IPR008114 - Septin3

Pfam Domains:
PF00735 - Septin
PF01926 - 50S ribosome-binding GTPase

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases
53474 - alpha/beta-Hydrolases
53795 - PEP carboxykinase-like

ModBase Predicted Comparative 3D Structure on Q9Z1S5
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0005525 GTP binding
GO:0042802 identical protein binding

Biological Process:
GO:0007049 cell cycle
GO:0051301 cell division

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0030054 cell junction
GO:0042734 presynaptic membrane
GO:0043005 neuron projection
GO:0045202 synapse
GO:0099569 presynaptic cytoskeleton


-  Descriptions from all associated GenBank mRNAs
  LF203252 - JP 2014500723-A/10755: Polycomb-Associated Non-Coding RNAs.
AF104411 - Mus musculus neuronal-specific septin 3 (Sep3) mRNA, complete cds.
BC055738 - Mus musculus septin 3, mRNA (cDNA clone MGC:67028 IMAGE:6413697), complete cds.
AK169916 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630004D10 product:septin 3, full insert sequence.
AK164861 - Mus musculus 15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930028P11 product:septin 3, full insert sequence.
AK046722 - Mus musculus adult male cortex cDNA, RIKEN full-length enriched library, clone:B530002E20 product:septin 3, full insert sequence.
AK030668 - Mus musculus 6 days neonate head cDNA, RIKEN full-length enriched library, clone:5430412N19 product:septin 3, full insert sequence.
AK141915 - Mus musculus 12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130062G19 product:septin 3, full insert sequence.
AK220520 - Mus musculus mRNA for mKIAA4169 protein.
MA438829 - JP 2018138019-A/10755: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_011889, Q3TNZ2, Q7TNT7, Q9Z1S5, Sep3, SEPT3_MOUSE, uc007wyq.1, uc007wyq.2
UCSC ID: uc007wyq.2
RefSeq Accession: NM_011889
Protein: Q9Z1S5 (aka SEPT3_MOUSE or SEP3_MOUSE)
CCDS: CCDS37157.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.