Mouse Gene Zfp740 (ENSMUST00000119800.7) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus zinc finger protein 740 (Zfp740), transcript variant 4, mRNA. (from RefSeq NM_001289695)
Gencode Transcript: ENSMUST00000119800.7
Gencode Gene: ENSMUSG00000046897.17
Transcript (Including UTRs)
   Position: mm10 chr15:102,204,609-102,215,606 Size: 10,998 Total Exon Count: 7 Strand: +
Coding Region
   Position: mm10 chr15:102,207,837-102,212,685 Size: 4,849 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:102,204,609-102,215,606)mRNA (may differ from genome)Protein (180 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeSOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ZN740_MOUSE
DESCRIPTION: RecName: Full=Zinc finger protein 740;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 3 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -140.50418-0.336 Picture PostScript Text
3' UTR -1096.002921-0.375 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF13894 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
55729 - Acyl-CoA N-acyltransferases (Nat)
57667 - beta-beta-alpha zinc fingers
57783 - Zinc beta-ribbon

ModBase Predicted Comparative 3D Structure on Q6NZQ6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008150 biological_process

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK144707 - Mus musculus lung RCB-0558 LLC cDNA, RIKEN full-length enriched library, clone:G730025D22 product:OriLyt TD-element binding protein 7 (Hypothetical protein) homolog [Homo sapiens], full insert sequence.
AK170207 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630030B01 product:similar to OriLyt TD-element binding protein 7 (Hypothetical protein) [Homo sapiens], full insert sequence.
AK193729 - Mus musculus cDNA, clone:Y1G0113D03, strand:unspecified.
BC066011 - Mus musculus zinc finger protein 740, mRNA (cDNA clone MGC:90089 IMAGE:6418561), complete cds.
BC030410 - Mus musculus zinc finger protein 740, mRNA (cDNA clone MGC:40784 IMAGE:5367159), complete cds.
AK180920 - Mus musculus cDNA, clone:Y0G0116F11, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000050860, based on BLAT search.
AK183663 - Mus musculus cDNA, clone:Y0G0126L07, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000050860, based on BLAT search.
AK190632 - Mus musculus cDNA, clone:Y1G0103F15, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000050860, based on BLAT search.
AB350336 - Mus musculus non-coding RNA, oocyte_piRNA1152, complete sequence.
DQ706313 - Mus musculus piRNA piR-121635, complete sequence.
AK004098 - Mus musculus 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110034O07 product:hypothetical protein, full insert sequence.
AK202835 - Mus musculus cDNA, clone:Y1G0142N12, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000050860, based on BLAT search.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q6NZQ6 (Reactome details) participates in the following event(s):

R-MMU-975040 KRAB-ZNF / KAP Interaction
R-MMU-212436 Generic Transcription Pathway
R-MMU-73857 RNA Polymerase II Transcription
R-MMU-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001289695, Q3UMS3, Q6NZQ6, Q8JZR3, uc007xuz.1, uc007xuz.2, uc007xuz.3, ZN740_MOUSE, Znf740
UCSC ID: uc007xuz.3
RefSeq Accession: NM_001289695
Protein: Q6NZQ6 (aka ZN740_MOUSE)
CCDS: CCDS70672.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.