ID:SPAG6_MOUSE DESCRIPTION: RecName: Full=Sperm-associated antigen 6; AltName: Full=Axoneme central apparatus protein; AltName: Full=Protein PF16 homolog; FUNCTION: Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. SUBUNIT: Interacts with SPAG16 AND SPAG17. INTERACTION: Q5S003:Spag17; NbExp=3; IntAct=EBI-1783654, EBI-1783665; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Note=Associated with microtubules. Detected on the sperm flagellum. TISSUE SPECIFICITY: Highly expressed in testis. Not detected in prostate, ovary, spleen, thymus, small intestine, colon and peripheral blood leukocytes. DISEASE: Note=Defects in Spag6 are a cause of hydrocephalus and of male infertility. DISRUPTION PHENOTYPE: In null embryos the central apparatus is unstable leading to a loss, and presumably degradation of proteins to which SPAG6 normally binds, including SPAG16 AND SPAG17. SIMILARITY: Contains 8 ARM repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9JLI7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.