The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8VDM4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0042176 regulation of protein catabolic process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0050790 regulation of catalytic activity
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu03050 - Proteasome
BioCyc Knowledge Library PWY3DJ-213 - Targeted protein degradation
Reactome (by CSHL, EBI, and GO)
Protein Q8VDM4 (Reactome details) participates in the following event(s):
R-MMU-5665871 ADRM1 binds 26S proteasome R-MMU-6798748 Exocytosis of secretory granule lumen proteins R-MMU-6800434 Exocytosis of ficolin-rich granule lumen proteins R-MMU-5665854 ADRM1:26S proteaseome binds UCHL5 R-MMU-5689539 ADRM1:26S proteaseome binds USP14 R-MMU-5689603 UCH proteinases R-MMU-6798695 Neutrophil degranulation R-MMU-5689880 Ub-specific processing proteases R-MMU-5688426 Deubiquitination R-MMU-68827 CDT1 association with the CDC6:ORC:origin complex R-MMU-68949 Orc1 removal from chromatin R-MMU-69017 CDK-mediated phosphorylation and removal of Cdc6 R-MMU-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-MMU-69229 Ubiquitin-dependent degradation of Cyclin D1 R-MMU-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-MMU-174154 APC/C:Cdc20 mediated degradation of Securin R-MMU-2467813 Separation of Sister Chromatids R-MMU-174113 SCF-beta-TrCP mediated degradation of Emi1 R-MMU-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-MMU-9020702 Interleukin-1 signaling R-MMU-349425 Autodegradation of the E3 ubiquitin ligase COP1 R-MMU-350562 Regulation of ornithine decarboxylase (ODC) R-MMU-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation R-MMU-1169091 Activation of NF-kappaB in B cells R-MMU-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-MMU-1236978 Cross-presentation of soluble exogenous antigens (endosomes) R-MMU-4641258 Degradation of DVL R-MMU-195253 Degradation of beta-catenin by the destruction complex R-MMU-4641257 Degradation of AXIN R-MMU-4608870 Asymmetric localization of PCP proteins R-MMU-5358346 Hedgehog ligand biogenesis R-MMU-202424 Downstream TCR signaling R-MMU-2871837 FCERI mediated NF-kB activation R-MMU-5607764 CLEC7A (Dectin-1) signaling R-MMU-5607761 Dectin-1 mediated noncanonical NF-kB signaling R-MMU-5676590 NIK-->noncanonical NF-kB signaling R-MMU-5610785 GLI3 is processed to GLI3R by the proteasome R-MMU-5610780 Degradation of GLI1 by the proteasome R-MMU-5632684 Hedgehog 'on' state R-MMU-5658442 Regulation of RAS by GAPs R-MMU-5668541 TNFR2 non-canonical NF-kB pathway R-MMU-5687128 MAPK6/MAPK4 signaling R-MMU-8948751 Regulation of PTEN stability and activity R-MMU-69481 G2/M Checkpoints R-MMU-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint R-MMU-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-MMU-382556 ABC-family proteins mediated transport R-MMU-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs R-MMU-174084 Autodegradation of Cdh1 by Cdh1:APC/C R-MMU-187577 SCF(Skp2)-mediated degradation of p27/p21 R-MMU-8939902 Regulation of RUNX2 expression and activity R-MMU-8941858 Regulation of RUNX3 expression and activity R-MMU-168249 Innate Immune System R-MMU-597592 Post-translational protein modification R-MMU-68867 Assembly of the pre-replicative complex R-MMU-69052 Switching of origins to a post-replicative state R-MMU-69610 p53-Independent DNA Damage Response R-MMU-75815 Ubiquitin-dependent degradation of Cyclin D R-MMU-174143 APC/C-mediated degradation of cell cycle proteins R-MMU-176409 APC/C:Cdc20 mediated degradation of mitotic proteins R-MMU-68882 Mitotic Anaphase R-MMU-176408 Regulation of APC/C activators between G1/S and early anaphase R-MMU-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-MMU-446652 Interleukin-1 family signaling R-MMU-69541 Stabilization of p53 R-MMU-351202 Metabolism of polyamines R-MMU-450531 Regulation of mRNA stability by proteins that bind AU-rich elements R-MMU-983169 Class I MHC mediated antigen processing & presentation R-MMU-1168372 Downstream signaling events of B Cell Receptor (BCR) R-MMU-1234174 Regulation of Hypoxia-inducible Factor (HIF) by oxygen R-MMU-1236975 Antigen processing-Cross presentation R-MMU-201681 TCF dependent signaling in response to WNT R-MMU-195721 Signaling by WNT R-MMU-4086400 PCP/CE pathway R-MMU-5358351 Signaling by Hedgehog R-MMU-202403 TCR signaling R-MMU-2454202 Fc epsilon receptor (FCERI) signaling R-MMU-5621481 C-type lectin receptors (CLRs) R-MMU-5610787 Hedgehog 'off' state R-MMU-5673001 RAF/MAP kinase cascade R-MMU-1280215 Cytokine Signaling in Immune system R-MMU-5683057 MAPK family signaling cascades R-MMU-6807070 PTEN Regulation R-MMU-69620 Cell Cycle Checkpoints R-MMU-69275 G2/M Transition R-MMU-382551 Transport of small molecules R-MMU-8878171 Transcriptional regulation by RUNX1 R-MMU-69202 Cyclin E associated events during G1/S transition R-MMU-69656 Cyclin A:Cdk2-associated events at S phase entry R-MMU-8878166 Transcriptional regulation by RUNX2 R-MMU-8878159 Transcriptional regulation by RUNX3 R-MMU-168256 Immune System R-MMU-392499 Metabolism of proteins R-MMU-69002 DNA Replication Pre-Initiation R-MMU-69239 Synthesis of DNA R-MMU-69613 p53-Independent G1/S DNA damage checkpoint R-MMU-69242 S Phase R-MMU-453276 Regulation of mitotic cell cycle R-MMU-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-MMU-2555396 Mitotic Metaphase and Anaphase R-MMU-449147 Signaling by Interleukins R-MMU-69563 p53-Dependent G1 DNA Damage Response R-MMU-71291 Metabolism of nitrogenous molecules R-MMU-8953854 Metabolism of RNA R-MMU-1280218 Adaptive Immune System R-MMU-983705 Signaling by the B Cell Receptor (BCR) R-MMU-2262749 Cellular response to hypoxia R-MMU-162582 Signal Transduction R-MMU-3858494 Beta-catenin independent WNT signaling R-MMU-5684996 MAPK1/MAPK3 signaling R-MMU-1257604 PIP3 activates AKT signaling R-MMU-1640170 Cell Cycle R-MMU-453274 Mitotic G2-G2/M phases R-MMU-212436 Generic Transcription Pathway R-MMU-69206 G1/S Transition R-MMU-68874 M/G1 Transition R-MMU-69306 DNA Replication R-MMU-69615 G1/S DNA Damage Checkpoints R-MMU-69278 Cell Cycle (Mitotic) R-MMU-68886 M Phase R-MMU-69580 p53-Dependent G1/S DNA damage checkpoint R-MMU-1430728 Metabolism R-MMU-2262752 Cellular responses to stress R-MMU-9006925 Intracellular signaling by second messengers R-MMU-73857 RNA Polymerase II Transcription R-MMU-453279 Mitotic G1-G1/S phases R-MMU-8953897 Cellular responses to external stimuli R-MMU-74160 Gene expression (Transcription)